Thrombin signaling in the brain: the role of protease-activated receptors (Q35098769)

6 August 2017

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title

Thrombin signaling in the brain: the role of protease-activated receptors (English)

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6 August 2017

Hong Wang

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6 August 2017

Georg Reiser

series ordinal

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6 August 2017

language of work or name

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1 February 2003

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6 August 2017

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6 August 2017

volume

384

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6 August 2017

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6 August 2017

page(s)

193-202

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Identification of thrombin receptors in rat brain capillary endothelial cells.

6 August 2017

cites work

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https://api.crossref.org/works/10.1515%2FBC.2003.021

The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain

21 January 2018

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Thrombin signalling and protease-activated receptors

21 January 2018

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Protease-activated receptors start a family

21 January 2018

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Prothrombin mRNA is expressed by cells of the nervous system

21 January 2018

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Thrombin is a regulator of astrocytic endothelin-1.

21 January 2018

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Thrombin attenuation is neuroprotective in the injured rat optic nerve

21 January 2018

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Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology

21 January 2018

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Serine proteases and brain damage - is there a link?

21 January 2018

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Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

21 January 2018

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Cytosolic phospholipase A2 and the distinct transcriptional programs of astrocytoma cells.

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International Union of Pharmacology. XXVIII. Proteinase-activated receptors

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Protease-activated receptor 3 is a second thrombin receptor in humans

21 January 2018

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Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers

21 January 2018

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Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

21 January 2018

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Thrombin-receptor activation and thrombin-induced brain tolerance

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A dual thrombin receptor system for platelet activation

21 January 2018

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

21 January 2018

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The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells.

21 January 2018

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Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function

21 January 2018

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Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton

21 January 2018

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A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responses

21 January 2018

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Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis.

21 January 2018

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Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells

21 January 2018

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Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin.

21 January 2018

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Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

21 January 2018

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Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

21 January 2018

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Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia

21 January 2018

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Geldanamycin specifically modulates thrombin-mediated morphological changes in mouse neuroblasts

21 January 2018

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Thrombin receptor signaling to cytoskeleton requires Hsp90.

21 January 2018

1 reference

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

21 January 2018

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cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

21 January 2018

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Mechanisms of cell death in primary cortical neurons and PC12 cells

21 January 2018

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Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain

21 January 2018

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Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

21 January 2018

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The structure of a complex of recombinant hirudin and human alpha-thrombin

21 January 2018

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The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets

21 January 2018

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Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation.

21 January 2018

1 reference

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Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis

21 January 2018

1 reference

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.021

Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.021

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

21 January 2018

1 reference

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Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

21 January 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

1 reference

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Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

21 January 2018

1 reference

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Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance

21 January 2018

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The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

21 January 2018

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Cloning and characterization of human protease-activated receptor 4

21 January 2018

1 reference

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Acute tissue damage after injections of thrombin and plasmin into rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.021

Hsp90: a specialized but essential protein-folding tool

21 January 2018

1 reference

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A novel PAR-1-type thrombin receptor signaling pathway: cyclic AMP-independent activation of PKA in SNB-19 glioblastoma cells.

21 January 2018

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Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1515/BC.2003.021

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6 August 2017

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