A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. (Q35073625)

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English	A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2.	scientific article

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2 February 2020

A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2 (English)

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2 February 2020

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2 February 2020

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Sangho Lee

1

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2 February 2020

Briana M Young

2

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2 February 2020

Wei Wan

3

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2 February 2020

Martin L Privalsky

5

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26 May 2011

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2 February 2020

Molecular Endocrinology

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2 February 2020

25

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2 February 2020

7

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2 February 2020

1111-1125

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2 February 2020

Molecular aspects of thyroid hormone actions

1 reference

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8 July 2018

The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors

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8 July 2018

A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo

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8 July 2018

Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity

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Nuclear receptors and human disease: resistance to thyroid hormone and lipodystrophic insulin resistance

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8 July 2018

Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination

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8 July 2018

International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors

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8 July 2018

Thyroid hormone resistance

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8 July 2018

Nuclear receptor corepressors

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8 July 2018

Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice

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8 July 2018

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance

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Pharmacology of nuclear receptor-coregulator recognition.

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Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters

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The role of corepressors in transcriptional regulation by nuclear hormone receptors

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Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells

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Follow-up of newborns with elevated screening T4 concentrations

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8 July 2018

Molecular basis of resistance to thyroid hormone.

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Thyroid hormone action: insight from transgenic mouse models

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Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function

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8 July 2018

Mechanism of thyroid hormone action

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Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors

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Tissue-specific actions of thyroid hormone: insights from animal models

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8 July 2018

Isoform-specific transcriptional regulation by thyroid hormone receptors: hormone-independent activation operates through a steroid receptor mode of co-activator interaction

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Physiological and molecular basis of thyroid hormone action

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8 July 2018

Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons

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8 July 2018

Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.

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8 July 2018

Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor

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Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.

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8 July 2018

DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia

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8 July 2018

A thyroid hormone receptor that is required for the development of green cone photoreceptors

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8 July 2018

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone

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Gene regulation by thyroid hormone

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Functions of thyroid hormone receptors in mice

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8 July 2018

Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators

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8 July 2018

Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex

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8 July 2018

Association between an R338L mutation in the thyroid hormone receptor-beta gene and thyrotoxic features in two unrelated kindreds with resistance to thyroid hormone.

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8 July 2018

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

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8 July 2018

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

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Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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8 July 2018

Phenotype differences of resistance to thyroid hormone in two unrelated families with an identical mutation in the thyroid hormone receptor beta gene (R320C).

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8 July 2018

Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone

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Multiple genetic factors in the heterogeneity of thyroid hormone resistance

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Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain

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The variable clinical phenotype in thyroid hormone resistance syndrome

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Mechanisms by which thyroid hormone receptor mutations cause clinical syndromes of resistance to thyroid hormone

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Ligand-Dependent and -Independent Transactivation by Thyroid Hormone Receptor β2 Is Determined by the Structure of the Hormone Response Element

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Phenotypic variability in patients with generalised resistance to thyroid hormone

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A structural role for hormone in the thyroid hormone receptor.

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8 July 2018

N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone

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27 September 2018

A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone

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Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation

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Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function.

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12 December 2020

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