Prodrugs of biologically active phosphate esters (Q35076887)

6 August 2017

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title

Prodrugs of biologically active phosphate esters (English)

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6 August 2017

Carsten Schultz

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6 August 2017

language of work or name

English

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publication date

1 March 2003

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Bioorganic & Medicinal Chemistry

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

885-898

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Pseudo-rotation in the hydrolysis of phosphate esters

6 August 2017

cites work

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7 January 2021

Minireview: nucleotide prodrugs

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7 January 2021

Synthesis and properties of some cyclic AMP alkyl phosphotriesters

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7 January 2021

Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate-benzyltriesters

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7 January 2021

N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors

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7 January 2021

Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine

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7 January 2021

cycloSal-pronucleotides design of chemical trojan horses

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7 January 2021

cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system

1 reference

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7 January 2021

cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

A novel connector linkage applicable in prodrug design

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7 January 2021

SOME NOVEL PENICILLIN DERIVATIVES

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7 January 2021

Acyloxymethyl esters of ampicillin

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Bacampicillin: a New Orally Well-Absorbed Derivative of Ampicillin

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7 January 2021

Biologically reversible phosphate-protective groups

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7 January 2021

Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP).

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7 January 2021

Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process

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7 January 2021

Synthesis and Studies of Mononucleoside Glucosyl Phosphotriester Derivatives

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Probing the Mechanism of Action and Decomposition of Amino Acid Phosphomonoester Amidates of Antiviral Nucleoside Prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and antiviral activity of phosphoralaninate derivatives of methylenecyclopropane analogues of nucleosides

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Activation mechanisms of nucleoside phosphoramidate prodrugs

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and biological activity of novel 5-fluoro-2'-deoxyuridine phosphoramidate prodrugs

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and evaluation of nitroheterocyclic phosphoramidates as hypoxia-selective alkylating agents.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Influence of a Calpha-substitution on the S-pivaloyl-2-thioethyl chain on the anti-HIV activity and stability of the resulting zidovudine mononucleoside phosphotriester

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and antiviral evaluation of SATE-foscarnet prodrugs and new foscarnet-AZT conjugates

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

1 reference

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7 January 2021

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

1 reference

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7 January 2021

Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Bisphosphonates: a review of their pharmacokinetic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The use of bisphosphonates in the treatment of osteoporosis

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7 January 2021

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Bisphosphonate prodrugs: synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Antitumor activity and toxicity of novel nitroheterocyclic phosphoramidates

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Inhibitory effect of cycloSaligenyl-nucleoside monophosphates (cycloSal-NMP) of acyclic nucleoside analogues on HSV-1 and EBV

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis, hydrolysis and anti-EBV activity of a series of 3'-modified cycloSal-BVDUMP pronucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis, anti-HIV activity, and stability studies of 5'-phosphorofluoridate derivatives of AZT.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Highly Efficient and Ultrafast Phototriggers for cAMP and cGMP by Using Long-Wavelength UV/Vis-Activation This work was supported by the Deutsche Forschungsgemeinschaft, the European Union, and the Fonds der Chemischen Industrie. We thank B. Dekowsk

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7 January 2021

Fluorescence spectroscopic quantification of the release of cyclic nucleotides from photocleavable [bis(carboxymethoxy)coumarin-4-yl]methyl esters inside cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Bioactivatable derivatives of 8-substituted cAMP-analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes

1 reference

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7 January 2021

Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation

1 reference

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7 January 2021

Antisense oligonucleotides: a new therapeutic principle

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Photocleavable Protecting Groups as Nucleobase Protections Allowed the Solid-Phase Synthesis of Base-Sensitive SATE-Prooligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

1 reference

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7 January 2021

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Inositol 1,3,4-Trisphosphate Actsin Vivoas a Specific Regulator of Cellular Signaling by Inositol 3,4,5,6-Tetrakisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl(-)-secretion from T84 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

d - myo -Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T84.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The phosphoinositide 3-kinase pathway

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

PI(4,5)P(2) regulation of surface membrane traffic

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Signalling through the lipid products of phosphoinositide-3-OH kinase

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

The role of phosphoinositides in membrane transport

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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

A membrane-permeant ester of phosphatidylinositol 3,4, 5-trisphosphate (PIP(3)) is an activator of human neutrophil migration

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900552-7

7 January 2021

10.1016/S0968-0896(02)00552-7

Identifiers

DOI

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6 August 2017

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