Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo (Q35067898)

6 August 2017

title

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo (English)

1 reference

6 August 2017

main subject

multiple drug resistance

1 reference

Xiao-Kun Wang

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6 August 2017

Kenneth Kin Wah To

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6 August 2017

Li-Yan Huang

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6 August 2017

Jing-Hong Xu

1 reference

6 August 2017

Ke Yang

1 reference

6 August 2017

Fang Wang

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6 August 2017

Zhen-Cong Huang

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6 August 2017

Sheng Ye

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6 August 2017

Li-Wu Fu

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6 August 2017

language of work or name

English

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publication date

1 December 2014

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

11971-11985

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Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.

6 August 2017

cites work

1 reference

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Rationale and design of LUX-Head & Neck 1: a randomised, Phase III trial of afatinib versus methotrexate in patients with recurrent and/or metastatic head and neck squamous cell carcinoma who progressed after platinum-based therapy

8 July 2018

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Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells

8 July 2018

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Reversal of ABCG2-mediated multidrug resistance by human cathelicidin and its analogs in cancer cells

8 July 2018

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Investigational ABC transporter inhibitors

8 July 2018

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A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab

8 July 2018

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The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

8 July 2018

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Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity

8 July 2018

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Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

8 July 2018

1 reference

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Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu

8 July 2018

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Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?

8 July 2018

1 reference

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Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

8 July 2018

1 reference

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Interaction of Tyrosine Kinase Inhibitors with the MDR-Related ABC Transporter Proteins

8 July 2018

1 reference

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ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy

8 July 2018

1 reference

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Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines.

8 July 2018

1 reference

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Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors?

8 July 2018

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BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors.

8 July 2018

1 reference

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Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Transport proteins of the ABC family and multidrug resistance of tumor cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

ABC multidrug transporters: structure, function and role in chemoresistance.

8 July 2018

1 reference

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The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Targeting multidrug resistance in cancer

8 July 2018

1 reference

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Role of ABCG2/BCRP in biology and medicine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

The tyrosine kinase inhibitors imatinib and AG957 reverse multidrug resistance in a chronic myelogenous leukemia cell line

8 July 2018

1 reference

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Tumour stem cells and drug resistance

8 July 2018

1 reference

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ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.

8 July 2018

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Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Targeting cancer cells by exploiting their resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line

8 July 2018

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Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Topoisomerase I as a target of erlotinib and gefitinib: efficacy of combined treatments with camptothecin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Breast cancer resistance protein and P-glycoprotein in 149 adult acute myeloid leukemias

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4322967

Antagonistic drug combinations that select against drug resistance: from bacteria to cancer

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25436978

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.2647

0 references

PMC publication ID

4322967

1 reference

6 August 2017

1 reference