Ras-effector interactions: after one decade (Q35064547)

6 August 2017

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title

Ras-effector interactions: after one decade (English)

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6 August 2017

Christian Herrmann

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6 August 2017

publication date

1 February 2003

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Current Opinion in Structural Biology

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

122-129

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Rho GTPases and their effector proteins

6 August 2017

cites work

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7 January 2021

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7 January 2021

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7 January 2021

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

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The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

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GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

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Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

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7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

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7 January 2021

Three-dimensional structure of the Ras-interacting domain of RalGDS

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7 January 2021

Solution structure of the Ras-binding domain of RGL

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Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf

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7 January 2021

Structural insights into phosphoinositide 3-kinase catalysis and signalling

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Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe

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7 January 2021

Structural basis for the interaction of Ras with RalGDS

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Structural and biochemical analysis of Ras-effector signaling via RalGDS

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast

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A novel family of Ras-binding domains

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Recent improvements to the SMART domain-based sequence annotation resource

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7 January 2021

Ras‐binding domains: predicting function versus folding

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The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

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Critical function of the Ras-associating domain as a primary Ras-binding site for regulation of Saccharomyces cerevisiae adenylyl cyclase

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7 January 2021

The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1

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7 January 2021

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

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7 January 2021

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

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A homochiral metal-organic porous material for enantioselective separation and catalysis

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7 January 2021

Flipping the switch: the structural basis for signaling through the CRIB motif

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7 January 2021

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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7 January 2021

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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7 January 2021

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

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7 January 2021

Structural view of the Ran-Importin beta interaction at 2.3 A resolution

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The guanine nucleotide-binding switch in three dimensions

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Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

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7 January 2021

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily

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7 January 2021

The many faces of Ras: recognition of small GTP-binding proteins

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7 January 2021

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

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7 January 2021

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7 January 2021

The atomic structure of protein-protein recognition sites

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7 January 2021

Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry

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7 January 2021

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

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7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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7 January 2021

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

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7 January 2021

Effector recognition by the small GTP-binding proteins Ras and Ral

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7 January 2021

Double-Mutant Analysis of the Interaction of Ras with the Ras-Binding Domain of RGL†

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7 January 2021

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

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7 January 2021

The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution

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7 January 2021

Dynamic properties of the Ras switch I region and its importance for binding to effectors

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7 January 2021

c-Raf-1 RBD associates with a subset of active v-H-Ras

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7 January 2021

Minimal catalytic domain of a group I self-splicing intron RNA

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7 January 2021

High-pressure NMR study of the complex of a GTPase Rap1A with its effector RalGDS. A conformational switch in RalGDS revealed from non-linear pressure shifts.

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7 January 2021

Low-lying excited states of proteins revealed from nonlinear pressure shifts in 1H and 15N NMR.

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7 January 2021

Two folded conformers of ubiquitin revealed by high-pressure NMR

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7 January 2021

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7 January 2021

Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase

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7 January 2021

Activation of phosphoinositide 3-kinase gamma by Ras.

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7 January 2021

10.1016/S0959-440X(02)00007-6

Identifiers

DOI

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6 August 2017

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