Prospects and pitfalls in whole genome association studies (Q35038066)

5 August 2017

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title

Prospects and pitfalls in whole genome association studies (English)

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5 August 2017

main subject

whole genome sequencing

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1 reference

5 August 2017

Robert W Lawrence

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5 August 2017

Lon R Cardon

series ordinal

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5 August 2017

language of work or name

English

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publication date

1 August 2005

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Philosophical Transactions of the Royal Society B

5 August 2017

published in

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5 August 2017

volume

360

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5 August 2017

issue

1460

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5 August 2017

page(s)

1589-1595

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Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Whole-genome patterns of common DNA variation in three human populations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Genome-wide association studies: theoretical and practical concerns

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Genome-wide association studies for common diseases and complex traits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Disease-specific target selection: a critical first step down the right road

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Linkage disequilibrium patterns vary substantially among populations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Genetic analysis of genome-wide variation in human gene expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Mapping complex disease loci in whole-genome association studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The fine-scale structure of recombination rate variation in the human genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The complex interplay among factors that influence allelic association.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The International HapMap Project

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Assessing the performance of the haplotype block model of linkage disequilibrium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Genetic associations in large versus small studies: an empirical assessment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The mosaic that is our genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

A bias-ed assessment of the use of SNPs in human complex traits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The structure of haplotype blocks in the human genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Patterns of linkage disequilibrium in the human genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

A coalescent-based method for detecting and estimating recombination from gene sequences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Estimating recombination rates from population genetic data

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Replication validity of genetic association studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Meiotic recombination hot spots and cold spots

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Association study designs for complex diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

How many diseases does it take to map a gene with SNPs?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

The future of genetic studies of complex human diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

High-resolution haplotype structure in the human genome

8 July 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

A genome-wide scalable SNP genotyping assay using microarray technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Human recombination hot spots hidden in regions of strong marker association

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

The impact of SNP density on fine-scale patterns of linkage disequilibrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Fine-scale recombination patterns differ between chimpanzees and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Linkage disequilibrium patterns of the human genome across populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Comparison of fine-scale recombination rates in humans and chimpanzees.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

A first-generation linkage disequilibrium map of human chromosome 22

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1689

The effect of haplotype-block definitions on inference of haplotype-block structure and htSNPs selection.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569530

Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16096108

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Islands of linkage disequilibrium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16096108

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence for substantial fine-scale variation in recombination rates across the human genome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16096108

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1098/RSTB.2005.1689

1 reference

5 August 2017

1 reference

5 August 2017

1 reference