Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. (Q34912378)

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English	Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.	scientific article

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23 January 2020

Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells (English)

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23 January 2020

apoptotic process

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Donald J Buchsbaum

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23 January 2020

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Hope M Amm

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23 January 2020

Tong Zhou

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23 January 2020

Adam D Steg

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23 January 2020

Huichien Kuo

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23 January 2020

Yufeng Li

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23 January 2020

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25 February 2011

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23 January 2020

Molecular Cancer Research

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23 January 2020

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23 January 2020

4

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23 January 2020

403-417

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23 January 2020

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

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Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins

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Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

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8 July 2018

The TRAIL to targeted therapy of breast cancer

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XIAP discriminates between type I and type II FAS-induced apoptosis

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8 July 2018

An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer

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Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

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8 July 2018

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †

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8 July 2018

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

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Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells

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8 July 2018

To kill a tumor cell: the potential of proapoptotic receptor agonists

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8 July 2018

Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody

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8 July 2018

BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells

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8 July 2018

Modulation of TRAIL-induced apoptosis by HDAC inhibitors

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8 July 2018

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

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8 July 2018

TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype

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8 July 2018

In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration

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8 July 2018

TRAIL therapy in non-small cell lung cancer cells: sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib.

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8 July 2018

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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8 July 2018

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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8 July 2018

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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8 July 2018

Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.

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8 July 2018

Metastatic breast cancer: an updating

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8 July 2018

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8 July 2018

Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study

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8 July 2018

Epigenetic information and estrogen receptor alpha expression in breast cancer

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8 July 2018

The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis

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8 July 2018

Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor

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8 July 2018

Facts and controversies in systemic treatment of metastatic breast cancer

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8 July 2018

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

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8 July 2018

Modulation of TRAIL signaling complex.

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8 July 2018

Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model

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8 July 2018

Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2.

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Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL

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Chemotherapy augments TRAIL-induced apoptosis in breast cell lines

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Effects of lipid chain length on molecular interactions between paclitaxel and phospholipid within model biomembranes

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