Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain (Q34892014)

5 August 2017

title

Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain (English)

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convection-enhanced delivery

5 August 2017

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magnetic resonance imaging

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author name string

R Mark Richardson

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5 August 2017

Adrian P Kells

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5 August 2017

Alastair J Martin

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5 August 2017

Paul S Larson

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5 August 2017

Philip A Starr

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5 August 2017

Peter G Piferi

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5 August 2017

Geoffrey Bates

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5 August 2017

Lisa Tansey

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5 August 2017

Kathryn H Rosenbluth

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5 August 2017

John R Bringas

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5 August 2017

Mitchel S Berger

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5 August 2017

Krystof S Bankiewicz

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5 August 2017

publication date

14 April 2011

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Stereotactic and functional neurosurgery

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

141-151

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Bioactivity of AAV2‐neurturin gene therapy (CERE‐120): Differences between Parkinson's disease and nonhuman primate brains

5 August 2017

cites work

1 reference

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Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

8 July 2018

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Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors

8 July 2018

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Image-guided convection-enhanced delivery of GDNF protein into monkey putamen

8 July 2018

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Poor drug distribution as a possible explanation for the results of the PRECISE trial

8 July 2018

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Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

8 July 2018

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Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates

8 July 2018

1 reference

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Image-guided convection-enhanced delivery of muscimol to the primate brain

8 July 2018

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Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy

8 July 2018

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Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys

8 July 2018

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Future applications: gene therapy.

8 July 2018

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Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys

8 July 2018

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Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys

8 July 2018

1 reference

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Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

8 July 2018

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Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models.

8 July 2018

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Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

8 July 2018

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Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.

8 July 2018

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Convective delivery of glial cell line-derived neurotrophic factor in the human putamen

8 July 2018

1 reference

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A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys

8 July 2018

1 reference

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

8 July 2018

1 reference

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Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents

8 July 2018

1 reference

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Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor

8 July 2018

1 reference

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Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

8 July 2018

1 reference

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Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging

8 July 2018

1 reference

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Brain biopsy sampling by using prospective stereotaxis and a trajectory guide.

8 July 2018

1 reference

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Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

8 July 2018

1 reference

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Microglia-specific localisation of a novel calcium binding protein, Iba1

8 July 2018

1 reference

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Convection-enhanced delivery of macromolecules in the brain

8 July 2018

1 reference

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Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

8 July 2018

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Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note

21 January 2018

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Prospective stereotaxy: a novel method of trajectory alignment using real-time image guidance

21 January 2018

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Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide.

21 January 2018

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Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging

21 January 2018

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Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase I/II clinical study.

21 January 2018

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Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin

21 January 2018

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Frameless stereotaxy using bone fiducial markers for deep brain stimulation

21 January 2018

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Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.

21 January 2018

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Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles

21 January 2018

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Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494065

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1159/000323544

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5 August 2017

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5 August 2017

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