Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation (Q34848771)

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English	Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

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ChEBI release 2020-05-28

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Bo-Yie Chen

1

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Europe PubMed Central

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4 August 2017

David Pei-Cheng Lin

2

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4 August 2017

Chia-Yung Wu

3

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Europe PubMed Central

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4 August 2017

Mei-Ching Teng

4

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Europe PubMed Central

PubMed publication ID

4 August 2017

Chi-Yun Sun

5

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Europe PubMed Central

PubMed publication ID

4 August 2017

Yuan-Ting Tsai

6

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Europe PubMed Central

PubMed publication ID

4 August 2017

Kuo-Chen Su

7

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Europe PubMed Central

PubMed publication ID

4 August 2017

Soo-Ray Wang

8

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4 August 2017

Han-Hsin Chang

9

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4 August 2017

publication date

6 April 2011

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4 August 2017

Molecular Vision

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4 August 2017

17

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Europe PubMed Central

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4 August 2017

854-863

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Europe PubMed Central

PubMed publication ID

4 August 2017

Structural and functional modifications of corneal crystallin ALDH3A1 by UVB light

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8 July 2018

Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity

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8 July 2018

Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide.

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8 July 2018

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-kappaB nuclear localization

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8 July 2018

Reconstruction of the corneal epithelium with induced marrow mesenchymal stem cells in rats

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8 July 2018

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

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8 July 2018

Selective transcription in response to an inflammatory stimulus

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8 July 2018

Congenital eye malformations associated with extensive periocular neural crest apoptosis after influenza B virus infection during early embryogenesis.

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8 July 2018

The resolution of inflammation: anti-inflammatory roles for NF-kappaB.

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8 July 2018

Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress

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8 July 2018

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

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8 July 2018

The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways.

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8 July 2018

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro.

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8 July 2018

In vitro covalent binding proteins of zerumbone, a chemopreventive food factor

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8 July 2018

Lornoxicam suppresses recurrent herpetic stromal keratitis through down-regulation of nuclear factor-kappaB: an experimental study in mice

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Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye.

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8 July 2018

In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa).

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8 July 2018

High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.

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8 July 2018

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

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8 July 2018

UV as an amplifier rather than inducer of NF-kappaB activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Lornoxicam protects mouse cornea from UVB-induced damage via inhibition of NF-{kappa}B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

The role of corneal crystallins in the cellular defense mechanisms against oxidative stress

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8 July 2018

Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals

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8 July 2018

Hedgehog is involved in prostate basal cell hyperplasia formation and its progressing towards tumorigenesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells

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8 July 2018

A mouse prostate cancer model induced by Hedgehog overexpression

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8 July 2018

Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Translocation of nuclear factor-kappaB on corneal epithelial cells induced by ultraviolet B irradiation.

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8 July 2018

Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081794

8 July 2018

Activation of nuclear factor-kappa B in the conjunctiva with the epithelial scraping of the mouse cornea and human epidemic keratoconjunctivitis

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8 July 2018

Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages

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8 July 2018

Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors

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8 July 2018

How light reaches the eye and its components

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8 July 2018

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

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8 July 2018

Repeated UVR exposures cause keratocyte resistance to apoptosis and hyaluronan accumulation in the rabbit cornea

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8 July 2018

Occupational exposure to ultraviolet radiation: a health risk assessment

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8 July 2018

The family of sunlight-related eye diseases.

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8 July 2018

Ultraviolet-B damages corneal endothelium.

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8 July 2018

The biological effects of UV-B on the eye.

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8 July 2018

Differential roles of nitric oxide synthases in regulation of ultraviolet B light-induced apoptosis

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26 October 2018

Ultraviolet B light-induced nitric oxide/peroxynitrite imbalance in keratinocytes--implications for apoptosis and necrosis

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Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.

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26 October 2018

Protective effect of 4-coumaric acid from UVB ray damage in the rabbit eye.

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26 October 2018

Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation

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26 October 2018

Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants

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26 October 2018

UVB-Elicited Induction of MMP-1 Expression in Human Ocular Surface Epithelial Cells Is Mediated through the ERK1/2 MAPK-Dependent Pathway

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26 October 2018

Cytoprotective effects of rebamipide and carteolol hydrochloride against ultraviolet B-induced corneal damage in mice.

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26 October 2018

Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet

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26 October 2018

Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation

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26 October 2018

Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light absorption properties of the rabbit cornea repeatedly irradiated with UVB rays

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultraviolet radiation-induced corneal degeneration in 129 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UV absorbance of the human cornea in the 240- to 400-nm range

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of glutathione and glutathione disulfide in biological samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural analysis of corneal exposure to UV radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21527993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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