Protein conjugation with genetically encoded unnatural amino acids (Q34838057)

4 August 2017

title

Protein conjugation with genetically encoded unnatural amino acids (English)

1 reference

4 August 2017

Peter G Schultz

1 reference

4 August 2017

Chan Hyuk Kim

1 reference

4 August 2017

Jun Y Axup

series ordinal

1 reference

4 August 2017

publication date

9 May 2013

1 reference

Current Opinion in Chemical Biology

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

412-419

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Self-assembled antibody multimers through peptide nucleic acid conjugation.

4 August 2017

cites work

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Genetically encoded cyclopropene directs rapid, photoclick-chemistry-mediated protein labeling in mammalian cells

8 July 2018

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Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

8 July 2018

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Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli.

8 July 2018

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Genetic Encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions

8 July 2018

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Synthesis of bispecific antibodies using genetically encoded unnatural amino acids.

8 July 2018

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Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

8 July 2018

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Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR.

8 July 2018

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Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes

8 July 2018

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

8 July 2018

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

8 July 2018

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RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

8 July 2018

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Rapid Chemoselective Bioconjugation through Oxidative Coupling of Anilines and Aminophenols

8 July 2018

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Expanding the genetic code of Escherichia coli with phosphoserine

8 July 2018

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Optimized clinical performance of growth hormone with an expanded genetic code

8 July 2018

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Genetically encoded copper-free click chemistry

8 July 2018

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Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma

8 July 2018

1 reference

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Cu-free click cycloaddition reactions in chemical biology

8 July 2018

1 reference

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Protein chemical modification on endogenous amino acids.

8 July 2018

1 reference

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Adding new chemistries to the genetic code

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

8 July 2018

1 reference

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Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

8 July 2018

1 reference

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Site-directed spin labeling of a genetically encoded unnatural amino acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Molecularly defined antibody conjugation through a selenocysteine interface

8 July 2018

1 reference

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Bispecific T-cell engaging antibodies for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Tetrazine-based cycloadditions: application to pretargeted live cell imaging

8 July 2018

1 reference

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Multistep engineering of pyrrolysyl-tRNA synthetase to genetically encode N(epsilon)-(o-azidobenzyloxycarbonyl) lysine for site-specific protein modification

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A genetically encoded boronate-containing amino acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Hydrolytic stability of hydrazones and oximes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Chemical probes shed light on protein function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Natural expansion of the genetic code

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A network of orthogonal ribosome x mRNA pairs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A genetically encoded photocaged amino acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Incorporation of nonnatural amino acids into proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

An expanded genetic code with a functional quadruplet codon

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Semisynthesis of proteins by expressed protein ligation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Addition of the keto functional group to the genetic code of Escherichia coli.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Expanding the genetic code of Escherichia coli

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Genetically encoded initiator for polymer growth from proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Genetically encoded alkenes in yeast

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Chemical production of bispecific antibodies

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284959

Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23664497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2013.04.017

1 reference

4 August 2017

1 reference

4 August 2017

1 reference