Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei (Q34800149)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378165%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei (English)

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24 January 2020

0 references

1 reference

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24 January 2020

Houtan Moshiri

1 reference

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24 January 2020

Stéphane Acoca

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24 January 2020

Smriti Kala

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24 January 2020

Hervé Hogues

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24 January 2020

Enrico Purisima

1 reference

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24 January 2020

Reza Salavati

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24 January 2020

language of work or name

English

0 references

publication date

4 March 2011

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24 January 2020

number of pages

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Journal of Biological Chemistry

inferred from page(s)

published in

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24 January 2020

volume

286

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24 January 2020

issue

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24 January 2020

page(s)

14178-14189

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Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Toward understanding the conformational dynamics of RNA ligation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Kinetoplastids: related protozoan pathogens, different diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

RNA editing in Trypanosoma brucei requires three different editosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Drugs and drug resistance in African trypanosomiasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Solvated interaction energy (SIE) for scoring protein-ligand binding affinities. 1. Exploring the parameter space.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

An essential RNase III insertion editing endonuclease in Trypanosoma brucei.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

H++: a server for estimating pKas and adding missing hydrogens to macromolecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Complex management: RNA editing in trypanosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

ZINC--a free database of commercially available compounds for virtual screening

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Comparative analysis of editosome proteins in trypanosomatids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Dyskinetoplastic Trypanosoma brucei contains functional editing complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

RBP38, a novel RNA-binding protein from trypanosomatid mitochondria, modulates RNA stability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Identification of novel components of Trypanosoma brucei editosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex business

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Distinct functions of two RNA ligases in active Trypanosoma brucei RNA editing complexes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Endoribonuclease activities of Trypanosoma brucei mitochondria.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Uptake and mode of action of drugs used against sleeping sickness.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Structural and mechanistic conservation in DNA ligases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Uridylate addition and RNA ligation contribute to the specificity of kinetoplastid insertion RNA editing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

RNA editing: getting U into RNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

Assembly of mitochondrial ribonucleoprotein complexes involves specific guide RNA (gRNA)-binding proteins and gRNA domains but does not require preedited mRNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

The IsTat 1.3 VSG multigene family inTrypanosoma bruceui: retention of the expression linked copy through multiple antigenic switches

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077619

A deletion site editing endonuclease in Trypanosoma brucei.

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

Molecular surface generation using a variable-radius solvent probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

Isolation of mitochondria from procyclic Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

Kinetoplastid RNA editing ligases 1 and 2 exhibit different electrostatic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.199646

RNA ligase and its involvement in guide RNA/mRNA chimera formation. Evidence for a cleavage-ligation mechanism of Trypanosoma brucei mRNA editing

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21378165

12 December 2020

inferred from PubMed ID database lookup

Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21378165

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M110.199646

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378165%20AND%20SRC:MED&resulttype=core&format=json

release_v2glefd54vghfijkt5x6bcfx3y

24 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v2glefd54vghfijkt5x6bcfx3y

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378165%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21378165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378165%20AND%20SRC:MED&resulttype=core&format=json