Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS). (Q34767547)

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English	Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS). (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

Alzheimer's disease

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4

object named as

Jörg Rademann

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Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

María Isabel Fernández-Bachiller

1

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Europe PubMed Central

PubMed publication ID

4 August 2017

André Horatscheck

2

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Europe PubMed Central

PubMed publication ID

4 August 2017

Michael Lisurek

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

publication date

11 June 2013

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

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Europe PubMed Central

PubMed publication ID

4 August 2017

7

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Europe PubMed Central

PubMed publication ID

4 August 2017

1041-1056

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Europe PubMed Central

PubMed publication ID

4 August 2017

Burden of Alzheimer's disease: population-based estimates and projections for New Zealand, 2006-2031

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Economics of dementia and pharmacoeconomics of dementia therapy

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

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Protease inhibitors: current status and future prospects

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

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Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease

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Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands

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Progress in the development of nonpeptidomimetic BACE 1 inhibitors for Alzheimer's disease

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors

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Fragment-based discovery of BACE1 inhibitors using functional assays

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Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering

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Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency

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Recent developments in fragment-based drug discovery

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A decade of fragment-based drug design: strategic advances and lessons learned

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The rise of fragment-based drug discovery

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Structural biology in fragment-based drug design

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Fragment screening by biochemical assay.

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Fragment based drug discovery using fluorescence correlation: spectroscopy techniques: challenges and solutions

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Dynamic template-assisted strategies in fragment-based drug discovery.

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Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.

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Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism

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Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

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A continuous time-resolved fluorescence assay for identification of BACE1 inhibitors.

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

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Peptide aldehydes as inhibitors of HIV protease.

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Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

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Identifiers

10.1002/CMDC.201300078

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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