Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a (Q34694788)

4 August 2017

title

Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a (English)

1 reference

4 August 2017

Han You

1 reference

4 August 2017

Kazuo Yamamoto

series ordinal

1 reference

4 August 2017

Tak Wah Mak

series ordinal

1 reference

4 August 2017

language of work or name

English

0 references

publication date

6 June 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

published in

1 reference

4 August 2017

volume

103

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4 August 2017

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4 August 2017

page(s)

9051-9056

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PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

4 August 2017

cites work

1 reference

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p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

7 July 2018

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

7 July 2018

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

7 July 2018

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

7 July 2018

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

7 July 2018

1 reference

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

7 July 2018

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

7 July 2018

1 reference

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p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

p53 has a direct apoptogenic role at the mitochondria

7 July 2018

1 reference

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

7 July 2018

1 reference

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C-terminal ubiquitination of p53 contributes to nuclear export

7 July 2018

1 reference

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

7 July 2018

1 reference

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

7 July 2018

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

7 July 2018

1 reference

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PUMA induces the rapid apoptosis of colorectal cancer cells

7 July 2018

1 reference

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Molecular biology. Getting p53 out of the nucleus.

7 July 2018

1 reference

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

7 July 2018

1 reference

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7 July 2018

Surfing the p53 network

1 reference

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

7 July 2018

1 reference

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How p53 binds DNA as a tetramer

7 July 2018

1 reference

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p53, the cellular gatekeeper for growth and division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

7 July 2018

1 reference

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Allosteric activation of latent p53 tetramers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Refined solution structure of the oligomerization domain of the tumour suppressor p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Solution structure of the tetrameric minimum transforming domain of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482564

Long-lived Drosophila with overexpressed dFOXO in adult fat body

7 July 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0600889103

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600889103

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600889103

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600889103

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600889103

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600889103

Analysis of p53 quaternary structure in relation to sequence-specific DNA binding

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16757565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0600889103

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference