The genetics of osteosarcoma (Q34639086)

3 August 2017

title

The genetics of osteosarcoma (English)

1 reference

3 August 2017

Jeremy A Squire

0 references

Jeff W Martin

1 reference

3 August 2017

Maria Zielenska

series ordinal

1 reference

3 August 2017

language of work or name

1 reference

20 May 2012

1 reference

3 August 2017

1 reference

3 August 2017

volume

2012

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3 August 2017

page(s)

627254

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Creative Commons Attribution 3.0 Unported

3 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyrighted

1 reference

April 2022 Public Data File from Crossref

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The breakage-fusion-bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma

7 July 2018

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Primary bone osteosarcoma in the pediatric age: state of the art.

7 July 2018

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

7 July 2018

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Identification of CCND3 and BYSL as candidate targets for the 6p21 amplification in diffuse large B-cell lymphoma.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Genetic instability in cancer: theory and experiment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Gene amplifications in osteosarcoma-CGH microarray analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Mutation analysis of the RECQL4 gene in sporadic osteosarcomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Evaluation of paediatric osteosarcomas by classic cytogenetic and CGH analyses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Etiology of osteosarcoma.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Linkage of Paget disease of bone to a novel region on human chromosome 18q23.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Chromosomal regions involved in the pathogenesis of osteosarcomas.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Genetic instabilities in human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Mutations of mitotic checkpoint genes in human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

A Mammalian Homolog of Fission Yeast Cdc5 Regulates G2 Progression and Mitotic Entry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Ring chromosomes in parosteal osteosarcoma contain sequences from 12q13-15: a combined cytogenetic and comparative genomic hybridization study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Frequent reduction or loss of DCC gene expression in human osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Bloom's syndrome. XX. The first 100 cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Oncogene alterations in primary, recurrent, and metastatic human bone tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Excess of rare cancers in Werner syndrome (adult progeria)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Frequency and structure of p53 rearrangements in human osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Interphase cytogenetics for the detection of the t(11;22)(q24;q12) in small round cell tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

7 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Analysis of miRNA-gene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Transient activation of the ALT pathway in human primary fibroblasts exposed to high-LET radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Alterations of the p53, Rb and MDM2 genes in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Comparative genomic hybridization analysis of abnormalities in chromosome 21 in childhood osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Analysis of segmental duplications, mouse genome synteny and recurrent cancer-associated amplicons in human chromosome 6p21-p12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Chromosome analysis of nine osteosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Analysis of 12q13-15 genes in parosteal osteosarcoma

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Malignant astrocytoma-derived region of common amplification in chromosomal band 17p12 is frequently amplified in high-grade osteosarcomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364016

Comparative genomic hybridization analysis identifies gains of 1p35∼p36 and chromosome 19 in osteosarcoma

26 October 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

High-resolution cDNA microarray CGH mapping of genomic imbalances in osteosarcoma using formalin-fixed paraffin-embedded tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F627254

Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas

21 January 2018

1 reference

12 December 2020

MDM2 gene amplification in metastatic osteosarcoma

1 reference

12 December 2020

Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma

1 reference

12 December 2020

DNA sequence copy number increase at 8q: a potential new prognostic marker in high-grade osteosarcoma

1 reference

12 December 2020

Mutation spectrum of the retinoblastoma gene in osteosarcomas

1 reference

12 December 2020

Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas

1 reference

12 December 2020

Sporadic amplification of the MYC gene in human osteosarcomas

1 reference

12 December 2020

Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma

1 reference

12 December 2020

COPS3 amplification and clinical outcome in osteosarcoma

1 reference

12 December 2020

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

1 reference

12 December 2020

Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

1 reference

12 December 2020

Familial occurrence of telangiectatic osteosarcoma: cousin cases

1 reference

12 December 2020

SAS is amplified predominantly in surface osteosarcoma

1 reference

12 December 2020

Allelic Losses from Chromosome 17 in Human Osteosarcomas

1 reference

12 December 2020

Translocation (11;22) in small cell osteosarcoma

1 reference

12 December 2020

Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes

1 reference

12 December 2020

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

1 reference

12 December 2020

Comparative genomic hybridization of low-grade central osteosarcoma

1 reference

12 December 2020

Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma

1 reference

12 December 2020

Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma

1 reference

12 December 2020

p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate

1 reference

12 December 2020

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma

1 reference

12 December 2020

Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma

1 reference

12 December 2020

Histopathological characterization of small cell osteosarcoma with immunohistochemistry and molecular genetic support. A study of 10 cases

1 reference

12 December 2020

Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization

1 reference

12 December 2020

Telomerase expression predicts unfavorable outcome in osteosarcoma

1 reference

12 December 2020

p53 gene mutations in osteosarcomas of low-grade malignancy

1 reference

12 December 2020

Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

1 reference

12 December 2020

Localization of a novel tumor suppressor locus on human chromosome 3q important in osteosarcoma tumorigenesis

1 reference

12 December 2020

Telangiectatic osteosarcoma: the St. Jude Children's Research Hospital's experience

1 reference

12 December 2020

MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone

1 reference

12 December 2020

Alterations of the p15, p16,and p18 genes in osteosarcoma

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/627254

1 reference

3 August 2017

1 reference

3 August 2017

1 reference