Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays (Q34608038)

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English	Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

natural product

1 reference

based on heuristic

inferred from title

Matthias Hamburger

2

object named as

Matthias Hamburger

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Olivier Potterat

1

object named as

Olivier Potterat

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

1 April 2013

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Natural Product Reports

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

546-564

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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Modern methods to produce natural-product libraries

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Drug-like properties: guiding principles for the design of natural product libraries.

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A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts

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Autographic assay for the rapid detection of antioxidant capacity of liquid and semi-solid pharmaceutical formulations using ABTS•+ immobilized by gel entrapment

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1 reference

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21 January 2018

Thin layer chromatography/mass spectrometry

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High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products

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Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

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Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

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Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization

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21 January 2018

Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS.

1 reference

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On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

1 reference

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Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

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Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry

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21 January 2018

Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization

1 reference

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21 January 2018

Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors

1 reference

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21 January 2018

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Antioxidant activity assays on-line with liquid chromatography

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection

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21 January 2018

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures.

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21 January 2018

Application of ABTS radical cation for selective on-line detection of radical scavengers in HPLC eluates

1 reference

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21 January 2018

Microfractionation revisited: a 1536 well high resolution screening assay.

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21 January 2018

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

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Structural elucidation of biologically active neomycin N-octyl derivatives in a regioisomeric mixture by means of liquid chromatography/ion trap time-of-flight mass spectrometry

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High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

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21 January 2018

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Bioassay-Guided Isolation of Epiquinamide, a Novel Quinolizidine Alkaloid and Nicotinic Agonist from an Ecuadoran Poison Frog,Epipedobatestricolor

1 reference

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21 January 2018

Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp.

1 reference

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21 January 2018

HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes

1 reference

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HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site

1 reference

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21 January 2018

HPLC-based activity profiling--discovery of sanggenons as GABAA receptor modulators in the traditional Chinese drug Sang bai pi (Morus alba root bark).

1 reference

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21 January 2018

Discovery of GABA(A) receptor modulator aristolactone in a commercial sample of the Chinese herbal drug "Chaihu" (Bupleurum chinense roots) unravels adulteration by nephrotoxic Aristolochia manshuriensis roots

1 reference

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21 January 2018

Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations

1 reference

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21 January 2018

Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.

1 reference

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21 January 2018

HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Positive GABAA Receptor Modulators from Acorus calamus and Structural Analysis of (+)-Dioxosarcoguaiacol by 1D and 2D NMR and Molecular Modeling

1 reference

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21 January 2018

HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root)

1 reference

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21 January 2018

Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Antitrypanosomal sesquiterpene lactones from Saussurea costus.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Screening and HPLC-Based Activity Profiling for New Antiprotozoal Leads from European Plants

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Antiplasmodial lanostanes from the Ganoderma lucidum mushroom

1 reference

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21 January 2018

Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Antiprotozoal isoflavan quinones from Abrus precatorius ssp. africanus

1 reference

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21 January 2018

Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts

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Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium.

1 reference

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21 January 2018

hERG Channel Inhibitors in Extracts of Coptidis Rhizoma

1 reference

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21 January 2018

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1 reference

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Application of an integrated LC-UV-MS-NMR platform to the identification of secondary metabolites from cell cultures: benzophenanthridine alkaloids from elicited Eschscholzia californica (california poppy) cell cultures().

1 reference

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21 January 2018

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1 reference

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21 January 2018

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1 reference

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1 reference

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21 January 2018

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1 reference

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21 January 2018

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1 reference

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21 January 2018

Recent developments in protein-ligand affinity mass spectrometry.

1 reference

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21 January 2018

Application of high-throughput affinity-selection mass spectrometry for screening of chemical compound libraries in lead discovery

1 reference

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21 January 2018

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1 reference

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21 January 2018

Unbiased binding assays for discovering small-molecule probes and drugs

1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Direct screening of natural product extracts using mass spectrometry.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Biochemical applications of mass spectrometry in pharmaceutical drug discovery

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

High-throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand-macromolecule interaction

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal immunoaffinity chromatography with mass spectrometric detection: a method for finding active compounds from traditional Chinese herbs

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography combined on-line with mass spectrometry: a tool for the binding study of different epidermal growth factor receptor inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Online magnetic bead dynamic protein-affinity selection coupled to LC-MS for the screening of pharmacologically active compounds.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Applications of pulsed ultrafiltration-mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Screening and structural characterization of alpha-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MS(n) and SORI-CID FTICR MS.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Identification of oleamide in Guatteria recurvisepala by LC/MS-based Plasmodium falciparum thioredoxin reductase ligand binding method

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Development of an ultrafiltration-liquid chromatography/mass spectrometry (UF-LC/MS) based ligand-binding assay and an LC/MS based functional assay for Mycobacterium tuberculosis shikimate kinase

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Evaluation of triterpene glycoside estrogenic activity using LC/MS and immunoaffinity extraction

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Screening of DHFR-binding drugs by MALDI-TOFMS.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Separation and screening of compounds of biological origin using molecularly imprinted polymers

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Imprinted polymers-tailor-made mimics of antibodies and receptors

1 reference

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21 January 2018

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications.

1 reference

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21 January 2018

Alternative affinity tools: more attractive than antibodies?

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid-phase extraction

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Direct extraction of specific pharmacophoric flavonoids from gingko leaves using a molecularly imprinted polymer for quercetin

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Selective separation of active inhibitors of epidermal growth factor receptor from Caragana Jubata by molecularly imprinted solid-phase extraction

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Recent advances in affinity capillary electrophoresis (2007).

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

A phthalide with in vitro growth inhibitory activity from an oidiodendron strain

1 reference

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21 January 2018

A Simple Method for High-Throughput Extract Prefractionation for Biological Screening

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

On-Line Detection of Antioxidative Activity in High-Performance Liquid Chromatography Eluates by Chemiluminescence

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

New mass spectrometric methods for the study of noncovalent associations of biopolymers

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Renaissance remedies: Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae)

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Differential Analysis of Mycoalexins in Confrontation Zones of Grapevine Fungal Pathogens by Ultrahigh Pressure Liquid Chromatography/Time-of-Flight Mass Spectrometry and Capillary Nuclear Magnetic Resonance

1 reference

https://api.crossref.org/works/10.1039%2FC3NP20094A

21 January 2018

Iridoid Glucosides with Free Radical Scavenging Properties fromFagraea blumei

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/HLCA.19970800411

New biflavonoid and other flavonoids from the leaves of Chimarrhis turbinata and their antioxidant activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1590/S0103-50532005000800008

Identifiers

10.1039/C3NP20094A

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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