Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects (Q34587170)

3 August 2017

title

Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects (English)

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3 August 2017

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Megan L Fluegel

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3 August 2017

Tracey J Parker

series ordinal

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3 August 2017

Leo J Pallanck

series ordinal

1 reference

3 August 2017

language of work or name

English

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publication date

3 August 2005

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3 August 2017

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3 August 2017

volume

172

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3 August 2017

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3 August 2017

page(s)

185-196

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Roles of ecdysone in Drosophila development

3 August 2017

cites work

1 reference

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

7 July 2018

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What's so special about cholesterol?

7 July 2018

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7 July 2018

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Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

7 July 2018

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Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone.

7 July 2018

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THE UTILIZATION OF STEROLS BY INSECTS

7 July 2018

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Niemann-Pick disease type C.

7 July 2018

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7 July 2018

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7 July 2018

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Transmembrane molecular pump activity of Niemann-Pick C1 protein

7 July 2018

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The structure and function of the Niemann-Pick C1 protein

7 July 2018

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daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans

7 July 2018

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7 July 2018

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Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

7 July 2018

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

7 July 2018

1 reference

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Intracellular cholesterol transport.

7 July 2018

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Niemann-Pick C disease: cholesterol handling gone awry

7 July 2018

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Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

7 July 2018

1 reference

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

7 July 2018

1 reference

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Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster

7 July 2018

1 reference

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Neurons producing specific neuropeptides in the central nervous system of normal and pupariation-delayed Drosophila

7 July 2018

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Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence

7 July 2018

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Lipophorin: the structure of an insect lipoprotein and its role in lipid transport in insects

7 July 2018

1 reference

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7 July 2018

1 reference

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The Biological Synthesis of Cholesterol

7 July 2018

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Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol

7 July 2018

1 reference

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The biochemical basis of the biosynthesis of cholesterol and fatty acids

7 July 2018

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A receptor-mediated pathway for cholesterol homeostasis

7 July 2018

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The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern

7 July 2018

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The ecdysoneless (ecd1ts) mutation disrupts ecdysteroid synthesis autonomously in the ring gland of Drosophila melanogaster.

7 July 2018

1 reference

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A stable genomic source of P element transposase in Drosophila melanogaster.

7 July 2018

1 reference

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The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

7 July 2018

1 reference

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Study on the composition-structure relationship of lipophorins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Flux of fatty acids through NPC1 lysosomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

The transport of low density lipoprotein-derived cholesterol to the plasma membrane is defective in NPC1 cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Embryonic assembly of a central pattern generator without sensory input.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Critical role for glycosphingolipids in Niemann-Pick disease type C.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

A model for niemann-pick type C disease in the nematode Caenorhabditis elegans

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

A Drosophila muscle-specific gene related to the mouse quaking locus

27 October 2018

1 reference

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Green fluorescent protein/β-galactosidase double reporters for visualizingDrosophila gene expression patterns

27 October 2018

1 reference

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Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Ecdysteroid production in Drosophila melanogaster reared on defined diets

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1456146

Intracellular cholesterol transport

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16079224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Some biochemical aspects of lipid and lipoprotein metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16079224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lipoproteins of human plasma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16079224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1534/GENETICS.105.046565

1 reference

3 August 2017

1 reference

3 August 2017

1 reference