The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs (Q34523564)

2 August 2017

title

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs (English)

1 reference

2 August 2017

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James E Dunford

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Michael J Rogers

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Stefan Knapp

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Udo Oppermann

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2 August 2017

Kathryn L Kavanagh

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2 August 2017

Kunde Guo

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2 August 2017

Xiaoqiu Wu

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2 August 2017

Frank H Ebetino

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2 August 2017

R Graham G Russell

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2 August 2017

language of work or name

English

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publication date

9 May 2006

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

103

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2 August 2017

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2 August 2017

page(s)

7829-7834

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Coot: model-building tools for molecular graphics

2 August 2017

cites work

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7 July 2018

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7 July 2018

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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

7 July 2018

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New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

7 July 2018

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Bisphosphonate mechanism of action

7 July 2018

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Incorporating target heterogeneity in drug design

7 July 2018

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9 December 2018

https://pubmed.ncbi.nlm.nih.gov/16684881

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

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Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

7 July 2018

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7 July 2018

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7 July 2018

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The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

7 July 2018

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

7 July 2018

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

7 July 2018

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Regulation of product chain length by isoprenyl diphosphate synthases

7 July 2018

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Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

7 July 2018

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Human liver prenyltransferase and its characterization

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs

7 July 2018

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3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

27 October 2018

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An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs

27 October 2018

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The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis

27 October 2018

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The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

27 October 2018

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

27 October 2018

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27 October 2018

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Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

27 October 2018

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Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

27 October 2018

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Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16684881

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0601643103

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference