Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex (Q34472898)

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17 December 2019

title

Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex (English)

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17 December 2019

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17 December 2019

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17 December 2019

Nils Holler

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17 December 2019

Aubry Tardivel

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17 December 2019

Magdalena Kovacsovics-Bankowski

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17 December 2019

Sylvie Hertig

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17 December 2019

Olivier Gaide

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17 December 2019

Antoine Tinel

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17 December 2019

David Deperthes

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17 December 2019

Silvio Calderara

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17 December 2019

Therese Schulthess

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17 December 2019

Jürgen Engel

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17 December 2019

Jürg Tschopp

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17 December 2019

language of work or name

English

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publication date

1 February 2003

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Molecular and Cellular Biology

17 December 2019

published in

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17 December 2019

volume

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17 December 2019

issue

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17 December 2019

page(s)

1428-1440

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Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar

17 December 2019

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Ceramide enables fas to cap and kill.

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Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.

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Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

6 July 2018

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

6 July 2018

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CD95's deadly mission in the immune system

6 July 2018

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Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis

6 July 2018

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Molecular basis for CD40 signaling mediated by TRAF3

6 July 2018

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Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.

6 July 2018

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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

6 July 2018

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Tumor necrosis factor receptor and Fas signaling mechanisms.

6 July 2018

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

6 July 2018

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An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

6 July 2018

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Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

6 July 2018

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Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.

6 July 2018

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Autoproteolytic activation of pro-caspases by oligomerization

6 July 2018

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Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

6 July 2018

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The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

6 July 2018

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Two CD95 (APO-1/Fas) signaling pathways

6 July 2018

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6 July 2018

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Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

6 July 2018

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

6 July 2018

1 reference

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The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis

6 July 2018

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

6 July 2018

1 reference

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Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

6 July 2018

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6 July 2018

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

6 July 2018

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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

6 July 2018

1 reference

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=141146

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=141146

FADD is required for multiple signaling events downstream of the receptor Fas.

6 July 2018

1 reference

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Biochemistry and function of the DISC

27 October 2018

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12 December 2020

Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins

1 reference

12 December 2020

A docking model of key components of the DISC complex: death domain superfamily interactions redefined

1 reference

12 December 2020

Phosphatidylinositol 3'-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95

1 reference

12 December 2020

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

1 reference

12 December 2020

Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154

1 reference

12 December 2020

Electron microscopy of extracellular matrix components

1 reference

12 December 2020

Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand

1 reference

12 December 2020

Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP)

1 reference

12 December 2020

Essential roles of the Fas ligand in the development of hepatitis

1 reference

12 December 2020

Fas/Fas ligand-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivilege in Hashimoto's thyroiditis

1 reference

12 December 2020

10.1128/MCB.23.4.1428-1440.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12556501%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

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17 December 2019

PubMed publication ID

12556501

1 reference

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