Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases (Q34478075)

2 August 2017

title

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases (English)

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2 August 2017

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Chongzhi Zang

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Naomi R Wray

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Bogdan Pasaniuc

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Christina M Hultman

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2 August 2017

Mark Daly

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2 August 2017

Stephan Ripke

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Soumya Raychaudhuri

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Patrick F Sullivan

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ORCID Public Data File 2021

2 August 2017

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Hannelore Ehrenreich

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ORCID Public Data File 2021

Tune H Pers

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ORCID Public Data File 2021

Benjamin M. Neale

object named as

Benjamin M Neale

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2 August 2017

Alkes L Price

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2 August 2017

Alexander Gusev

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2 August 2017

S Hong Lee

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2 August 2017

Gosia Trynka

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2 August 2017

Hilary Finucane

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2 August 2017

Bjarni J Vilhjálmsson

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2 August 2017

Han Xu

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2 August 2017

Brendan Bulik-Sullivan

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2 August 2017

Eli Stahl

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2 August 2017

Schizophrenia Working Group of the Psychiatric Genomics Consortium

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2 August 2017

SWE-SCZ Consortium

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2 August 2017

Anna K Kähler

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2 August 2017

Shaun M Purcell

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2 August 2017

Steven A McCarroll

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2 August 2017

Schizophrenia Working Group of the Psychiatric Genomics Consortium

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2 August 2017

SWE-SCZ Consortium

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2 August 2017

language of work or name

English

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publication date

6 November 2014

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American Journal of Human Genetics

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

535-552

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Mixed model with correction for case-control ascertainment increases association power

2 August 2017

cites work

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6 July 2018

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Biological insights from 108 schizophrenia-associated genetic loci

6 July 2018

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Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A polygenic burden of rare disruptive mutations in schizophrenia

6 July 2018

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Quantifying missing heritability at known GWAS loci

6 July 2018

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Exonic transcription factor binding directs codon choice and affects protein evolution

6 July 2018

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Meta-analysis of gene-level tests for rare variant association

6 July 2018

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Estimation of SNP heritability from dense genotype data

6 July 2018

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Beyond GWASs: illuminating the dark road from association to function

6 July 2018

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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

6 July 2018

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Functional transcriptomics in the post-ENCODE era

6 July 2018

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Identification of genetic variants that affect histone modifications in human cells

6 July 2018

1 reference

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Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease

6 July 2018

1 reference

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Transcriptome and genome sequencing uncovers functional variation in humans

6 July 2018

1 reference

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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

6 July 2018

1 reference

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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

6 July 2018

1 reference

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General framework for meta-analysis of rare variants in sequencing association studies

6 July 2018

1 reference

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Systematic functional regulatory assessment of disease-associated variants.

6 July 2018

1 reference

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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

6 July 2018

1 reference

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Polygenic modeling with bayesian sparse linear mixed models

6 July 2018

1 reference

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Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

6 July 2018

1 reference

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Chromatin marks identify critical cell types for fine mapping complex trait variants

6 July 2018

1 reference

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6 July 2018

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Improved heritability estimation from genome-wide SNPs

6 July 2018

1 reference

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An integrated map of genetic variation from 1,092 human genomes

6 July 2018

1 reference

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Bayesian refinement of association signals for 14 loci in 3 common diseases

6 July 2018

1 reference

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Estimating genetic effects and quantifying missing heritability explained by identified rare-variant associations

6 July 2018

1 reference

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Linking disease associations with regulatory information in the human genome

6 July 2018

1 reference

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Systematic localization of common disease-associated variation in regulatory DNA

6 July 2018

1 reference

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An expansive human regulatory lexicon encoded in transcription factor footprints

6 July 2018

1 reference

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The accessible chromatin landscape of the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

An integrated encyclopedia of DNA elements in the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Phasing of many thousands of genotyped samples

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Inferences from genomic models in stratified populations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Incorporating prior information into association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

DNase I sensitivity QTLs are a major determinant of human expression variation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Dissecting the regulatory architecture of gene expression QTLs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Rare and common variants: twenty arguments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Five years of GWAS discovery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Genome partitioning of genetic variation for complex traits using common SNPs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Mapping and analysis of chromatin state dynamics in nine human cell types

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Estimating Missing Heritability for Disease from Genome-wide Association Studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

GCTA: a tool for genome-wide complex trait analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

The NIH Roadmap Epigenomics Mapping Consortium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Common SNPs explain a large proportion of the heritability for human height

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Genotype imputation for genome-wide association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

6 July 2018

1 reference

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A method and server for predicting damaging missense mutations

6 July 2018

1 reference

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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

6 July 2018

1 reference

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Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

6 July 2018

1 reference

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

6 July 2018

1 reference

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Model-based analysis of ChIP-Seq (MACS)

6 July 2018

1 reference

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Increasing power in association studies by using linkage disequilibrium structure and molecular function as prior information

6 July 2018

1 reference

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Principal components analysis corrects for stratification in genome-wide association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Population structure, differential bias and genomic control in a large-scale, case-control association study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

A fine-scale map of recombination rates and hotspots across the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Computing approximate standard errors for genetic parameters derived from random regression models fitted by average information REML

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

DIST: direct imputation of summary statistics for unmeasured SNPs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Evidence of abundant purifying selection in humans for recently acquired regulatory functions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Bayes factors for genome-wide association studies: comparison with P-values

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225595

Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies

27 October 2018

1 reference

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The investigation of linkage between a quantitative trait and a marker locus

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25439723

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.AJHG.2014.10.004

1 reference

2 August 2017

1 reference

2 August 2017

1 reference