Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program (Q34475754)

24664981

2 August 2017

title

Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program (English)

1 reference

2 August 2017

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11 June 2020

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11 June 2020

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11 June 2020

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11 June 2020

Peter J Houghton

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11 June 2020

Min H Kang

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11 June 2020

John M Maris

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11 June 2020

Raushan T Kurmasheva

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11 June 2020

E Anders Kolb

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11 June 2020

Stephen T Keir

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11 June 2020

Hernan Carol

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11 June 2020

Dmitry Lyalin

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11 June 2020

Jianrong Wu

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11 June 2020

language of work or name

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24 March 2014

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24664981

2 August 2017

published in

Pediatric Blood & Cancer

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11 June 2020

volume

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11 June 2020

issue

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11 June 2020

page(s)

1493-1496

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Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models

11 June 2020

cites work

1 reference

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Targeting the Notch pathway: twists and turns on the road to rational therapeutics

6 July 2018

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Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia

6 July 2018

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The double-edged sword of Notch signaling in cancer

6 July 2018

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Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

6 July 2018

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Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion

6 July 2018

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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.

6 July 2018

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Notch Pathway Inhibition Significantly Reduces Rhabdomyosarcoma Invasiveness and Mobility In Vitro

6 July 2018

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Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.

6 July 2018

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Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

6 July 2018

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National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing

6 July 2018

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Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

6 July 2018

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Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

6 July 2018

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Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

6 July 2018

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Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

6 July 2018

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Notch signaling contributes to the pathogenesis of human osteosarcomas

6 July 2018

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Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program

6 July 2018

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Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

6 July 2018

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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

6 July 2018

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Notch signaling, gamma-secretase inhibitors, and cancer therapy

6 July 2018

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

6 July 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

6 July 2018

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Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

6 July 2018

1 reference

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Notch signaling: cell fate control and signal integration in development

6 July 2018

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The pediatric preclinical testing program: description of models and early testing results.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FPBC.25026

21 January 2018

Identifiers

DOI

10.1002/PBC.25026

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24664981%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24664981%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

24664981

1 reference

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