Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins (Q34461300)

25652038

2 August 2017

title

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins (English)

1 reference

2 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25652038%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Katherine H Schreiber

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1 June 2020

Denise Ortiz

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1 June 2020

Emmeline C Academia

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1 June 2020

Arieanna C Anies

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1 June 2020

Chen-Yu Liao

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1 June 2020

language of work or name

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4 February 2015

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2 August 2017

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1 June 2020

volume

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1 June 2020

issue

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1 June 2020

page(s)

265-273

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25652038%20AND%20SRC:MED&resulttype=core&format=json

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

1 June 2020

cites work

1 reference

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Late-life rapamycin treatment reverses age-related heart dysfunction.

6 July 2018

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

6 July 2018

1 reference

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Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

6 July 2018

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mTOR signaling in growth control and disease

6 July 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

6 July 2018

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

6 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

6 July 2018

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TOR and ageing: a complex pathway for a complex process.

6 July 2018

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With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

6 July 2018

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

6 July 2018

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

6 July 2018

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

6 July 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

6 July 2018

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

6 July 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

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The TOR pathway comes of age

6 July 2018

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6 July 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Extension of chronological life span in yeast by decreased TOR pathway signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Genes determining yeast replicative life span in a long-lived genetic background

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

TOR pathway: linking nutrient sensing to life span

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

6 July 2018

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Genetics: influence of TOR kinase on lifespan in C. elegans

6 July 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

6 July 2018

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Regulation of longevity and stress resistance by Sch9 in yeast

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4364838

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

6 July 2018

1 reference

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mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

6 July 2018

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Crossref

https://api.crossref.org/works/10.1111%2FACEL.12313

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

21 January 2018

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Crossref

https://api.crossref.org/works/10.1111%2FACEL.12313

21 January 2018

Identifiers

DOI

10.1111/ACEL.12313

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25652038%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25652038%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25652038

1 reference

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