Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity (Q34443867)

2 August 2017

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title

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity (English)

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2 August 2017

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Manajit K Hayer-Hartl

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F Ulrich Hartl

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2 August 2017

Hideki Sakahira

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2 August 2017

Peter Breuer

series ordinal

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2 August 2017

language of work or name

English

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publication date

20 August 2002

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

99 Suppl 4

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2 August 2017

page(s)

16412-16418

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Chaperoning brain degeneration

2 August 2017

cites work

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6 July 2018

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6 July 2018

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6 July 2018

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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

6 July 2018

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An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloid

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

6 July 2018

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6 July 2018

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6 July 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

6 July 2018

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6 July 2018

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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

6 July 2018

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

6 July 2018

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6 July 2018

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

6 July 2018

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6 July 2018

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

6 July 2018

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6 July 2018

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Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

6 July 2018

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

6 July 2018

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6 July 2018

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Glutamine repeats and neurodegenerative diseases: molecular aspects

6 July 2018

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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

The fundamentals of protein folding: bringing together theory and experiment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

A cellular model that recapitulates major pathogenic steps of Huntington's disease

6 July 2018

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

6 July 2018

1 reference

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Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

The Hsp70 and Hsp60 chaperone machines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Modulation of intracellular protein degradation by SSB1-SIS1 chaperon system in yeast S. cerevisiae.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Initial process of polyglutamine aggregate formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Recruitment of a 19S proteasome subcomplex to an activated promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Two-dimensional structure of beta-amyloid(10-35) fibrils

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139902

Isolation of neuronal cells with high processing activity for the Machado-Joseph disease protein

27 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.182426899

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

21 January 2018

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12 December 2020

Mechanisms of amyloidogenesis

1 reference

12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

12 December 2020

J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.182426899

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2 August 2017

0 references

1 reference

2 August 2017

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