Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists. (Q34435684)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848155%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists (English)

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18 March 2020

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18 March 2020

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18 March 2020

Jianyong Chen

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18 March 2020

Beth Levant

series ordinal

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18 March 2020

Cheng Jiang

series ordinal

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18 March 2020

Amy Hauck Newman

series ordinal

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18 March 2020

language of work or name

English

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publication date

3 June 2014

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Journal of Medicinal Chemistry

18 March 2020

published in

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18 March 2020

volume

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18 March 2020

issue

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18 March 2020

page(s)

4962-4968

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Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design

18 March 2020

cites work

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Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

6 July 2018

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CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist

6 July 2018

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YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self‐administration in rats and mice, but not in D3 receptor‐knockout mice

6 July 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

6 July 2018

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Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

6 July 2018

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N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

6 July 2018

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Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents

6 July 2018

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Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery

6 July 2018

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The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

6 July 2018

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Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents

6 July 2018

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Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor

6 July 2018

1 reference

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Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists

6 July 2018

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Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A

6 July 2018

1 reference

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Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

6 July 2018

1 reference

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Positron emission tomographic analysis of dose-dependent MDL 100,907 binding to 5-hydroxytryptamine-2A receptors in the human brain

6 July 2018

1 reference

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Binding of [3H]PD 128907, a putatively selective ligand for the D3 dopamine receptor, in rat brain: a receptor binding and quantitative autoradiographic study

6 July 2018

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

6 July 2018

1 reference

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Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

6 July 2018

1 reference

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The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors

6 July 2018

1 reference

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Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain

6 July 2018

1 reference

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies

6 July 2018

1 reference

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Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists

27 October 2018

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Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

27 October 2018

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Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

27 October 2018

1 reference

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Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

27 October 2018

1 reference

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Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist

27 October 2018

1 reference

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Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

27 October 2018

1 reference

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N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands

27 October 2018

1 reference

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Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors

27 October 2018

1 reference

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27 October 2018

Identifiers

DOI

10.1021/JM401798R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848155%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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18 March 2020

PubMed publication ID

24848155

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