Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. (Q34409608)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25348413%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism (English)

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21 February 2020

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21 February 2020

Yu Zhou

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21 February 2020

publication date

1 November 2014

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25348413%20AND%20SRC:MED&resulttype=core&format=json

The Journal of General Physiology

21 February 2020

published in

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21 February 2020

volume

144

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21 February 2020

issue

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21 February 2020

page(s)

415-440

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BK channel opening involves side-chain reorientation of multiple deep-pore residues

21 February 2020

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Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

6 July 2018

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Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.

6 July 2018

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BK channels in innate immune functions of neutrophils and macrophages

6 July 2018

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6 July 2018

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6 July 2018

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Access and binding of local anesthetics in the closed sodium channel

6 July 2018

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State-independent block of BK channels by an intracellular quaternary ammonium

6 July 2018

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Probing the geometry of the inner vestibule of BK channels with sugars

6 July 2018

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

6 July 2018

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Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels

6 July 2018

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Conserved gating hinge in ligand- and voltage-dependent K+ channels

6 July 2018

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Pharmacological evidence for a key role of voltage-gated K+ channels in the function of rat aortic smooth muscle cells

6 July 2018

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A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom

6 July 2018

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BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampus

6 July 2018

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TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS

6 July 2018

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A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore

6 July 2018

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Bioprotective Alkaloids of Grass-Fungal Endophyte Symbioses

6 July 2018

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Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels

6 July 2018

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The open pore conformation of potassium channels

6 July 2018

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Crystal structure and mechanism of a calcium-gated potassium channel

6 July 2018

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Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site

6 July 2018

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6 July 2018

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Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

6 July 2018

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A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin

6 July 2018

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Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).

6 July 2018

1 reference

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Structural rearrangements underlying K+-channel activation gating

6 July 2018

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Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells

6 July 2018

1 reference

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

6 July 2018

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Tetracaine Reports a Conformational Change in the Pore of Cyclic Nucleotide–gated Channels

6 July 2018

1 reference

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Redox modulation of hslo Ca2+-activated K+ channels

6 July 2018

1 reference

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Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210426

Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210426

Mechanism of tetracaine block of cyclic nucleotide-gated channels

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210426

Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210426

The internal quaternary ammonium receptor site of Shaker potassium channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210426

Tetrodotoxin Derivatives: Chemical Structure and Blockage of Nerve Membrane Conductance

6 July 2018

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Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons

6 July 2018

1 reference

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The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier

6 July 2018

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Anomalous voltage dependence of channel blockade at a crustacean glutamate-mediated synapse

6 July 2018

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Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel

6 July 2018

1 reference

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Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength

6 July 2018

1 reference

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Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels

6 July 2018

1 reference

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Local anaesthetics transiently block currents through single acetylcholine-receptor channels

6 July 2018

1 reference

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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

6 July 2018

1 reference

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Drug blockade of open end-plate channels

6 July 2018

1 reference

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Agitoxin footprinting the shaker potassium channel pore

6 July 2018

1 reference

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Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411259

Structural basis of TEA blockade in a model potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411259

State-dependent block of BK channels by synthesized shaker ball peptides

21 January 2018

1 reference

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Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel

21 January 2018

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12 December 2020

The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells

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12 December 2020

Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels

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12 December 2020

Energetics of pore opening in a voltage-gated K(+) channel

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12 December 2020

Identifiers

DOI

10.1085/JGP.201411259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25348413%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25348413%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25348413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25348413%20AND%20SRC:MED&resulttype=core&format=json