Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond (Q34288747)

1 August 2017

title

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond (English)

1 reference

Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

1 August 2017

corrigendum / erratum

1 reference

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NRN3317

1 reference

1 August 2017

language of work or name

English

0 references

publication date

18 July 2012

1 reference

Nature Reviews Neuroscience

1 August 2017

published in

1 reference

1 August 2017

1 reference

1 August 2017

1 reference

1 August 2017

page(s)

542-555

1 reference

Structure and regulation of voltage-gated Ca2+ channels

1 August 2017

cites work

1 reference

A short history of voltage-gated calcium channels

21 January 2018

1 reference

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels

21 January 2018

1 reference

The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.

21 January 2018

1 reference

Calcium channel gamma subunits: a functionally diverse protein family

21 January 2018

1 reference

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

21 January 2018

1 reference

Primary structure of the receptor for calcium channel blockers from skeletal muscle

21 January 2018

1 reference

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.

21 January 2018

1 reference

The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression

21 January 2018

1 reference

21 January 2018

1 reference

Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels

21 January 2018

1 reference

Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness

21 January 2018

1 reference

Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina

21 January 2018

1 reference

Structural and functional differences between L-type calcium channels: crucial issues for future selective targeting

21 January 2018

1 reference

Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models

21 January 2018

1 reference

Voltage-gated calcium channels

21 January 2018

1 reference

Molecular physiology of low-voltage-activated t-type calcium channels

21 January 2018

1 reference

T-type Ca2+ channels as therapeutic targets in the nervous system

21 January 2018

1 reference

Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity

21 January 2018

1 reference

Beta subunit heterogeneity in neuronal L-type Ca2+ channels

21 January 2018

1 reference

Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain

21 January 2018

1 reference

Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels

21 January 2018

1 reference

Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels

21 January 2018

1 reference

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere

21 January 2018

1 reference

Calcium channel alpha2delta subunits: differential expression, function, and drug binding

21 January 2018

1 reference

Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit

21 January 2018

1 reference

Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit

21 January 2018

1 reference

Genomic organization of the mouse and human alpha2delta2 voltage-dependent calcium channel subunit genes

21 January 2018

1 reference

Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit

21 January 2018

1 reference

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.

21 January 2018

1 reference

The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

21 January 2018

1 reference

Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit

21 January 2018

1 reference

3D structure of the skeletal muscle dihydropyridine receptor

21 January 2018

1 reference

Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy.

21 January 2018

1 reference

Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture

21 January 2018

1 reference

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels

21 January 2018

1 reference

Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors

21 January 2018

1 reference

Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.

21 January 2018

1 reference

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury

21 January 2018

1 reference

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

21 January 2018

1 reference

Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (alpha2-delta) type 1 protein

21 January 2018

1 reference

Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutation

21 January 2018

1 reference

Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy

21 January 2018

1 reference

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

21 January 2018

1 reference

Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses

21 January 2018

1 reference

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

21 January 2018

1 reference

The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.

21 January 2018

1 reference

Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function

21 January 2018

1 reference

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha(2)delta subunit UNC-36

21 January 2018

1 reference

G protein modulation of voltage-gated calcium channels

21 January 2018

1 reference

Kinetics of internalization and degradation of N-type voltage-gated calcium channels: role of the alpha2/delta subunit

21 January 2018

1 reference

Extracellular Interaction of the Voltage-dependent Ca2+ Channel α2δ and α1 Subunits

21 January 2018

1 reference

Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction.

21 January 2018

1 reference

The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

21 January 2018

1 reference

Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)

21 January 2018

1 reference

Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer

21 January 2018

1 reference

CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity

21 January 2018

1 reference

Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions

21 January 2018

1 reference

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis

21 January 2018

1 reference

Thrombospondins in cancer

21 January 2018

1 reference

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death.

21 January 2018

1 reference

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

21 January 2018

1 reference

De Novo Gene Disruptions in Children on the Autistic Spectrum

21 January 2018

1 reference

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

21 January 2018

1 reference

Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation

21 January 2018

1 reference

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

21 January 2018

1 reference

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

21 January 2018

1 reference

entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse

21 January 2018

1 reference

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

21 January 2018

1 reference

Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy

21 January 2018

1 reference

From basic science to blockbuster drug: the discovery of Lyrica

21 January 2018

1 reference

Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery

21 January 2018

1 reference

Pregabalin for postherpetic neuralgia: placebo-controlled trial of fixed and flexible dosing regimens on allodynia and time to onset of pain relief

21 January 2018

1 reference

Pains, gains, and midbrains

21 January 2018

1 reference

Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes

21 January 2018

1 reference

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

21 January 2018

1 reference

Spermine modulation of specific [3H]-gabapentin binding to the detergent-solubilized porcine cerebral cortex alpha 2 delta calcium channel subunit

21 January 2018

1 reference

Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine

21 January 2018

1 reference

Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy

21 January 2018

1 reference

Gabapentin inhibits calcium currents in isolated rat brain neurons

21 January 2018

1 reference

Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.

21 January 2018

1 reference

Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones

21 January 2018

1 reference

Newer-Generation Antiepileptic Drugs and the Risk of Major Birth Defects

21 January 2018

1 reference

Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register

21 January 2018

1 reference

Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle

21 January 2018

1 reference

The β Subunit of Voltage-Gated Ca2+Channels

21 January 2018

1 reference

Modelling of a voltage-dependent Ca2+ channel beta subunit as a basis for understanding its functional properties

21 January 2018

1 reference

Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins

21 January 2018

1 reference

Calcium channel function regulated by the SH3-GK module in beta subunits

21 January 2018

1 reference

Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain

21 January 2018

1 reference

Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain.

21 January 2018

1 reference

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels

21 January 2018

1 reference

N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.

21 January 2018

1 reference

Oligomerization of Cavβ subunits is an essential correlate of Ca2+channel activity

21 January 2018

1 reference

Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.

21 January 2018

1 reference

Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma.

21 January 2018

1 reference

Folding of active calcium channel beta(1b) -subunit by size-exclusion chromatography and its role on channel function.

21 January 2018

1 reference

The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels

21 January 2018

1 reference

Enhancement of ionic current and charge movement by coexpression of calcium channel beta 1A subunit with alpha 1C subunit in a human embryonic kidney cell line.

21 January 2018

1 reference

Importance of the different beta subunits in the membrane expression of the alpha1A and alpha2 calcium channel subunits: studies using a depolarization-sensitive alpha1A antibody

21 January 2018

1 reference

The I-II loop of the Ca2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit.

21 January 2018

1 reference

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties

21 January 2018

1 reference

Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel

21 January 2018

1 reference

Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation

21 January 2018

1 reference

Determinants of the G protein-dependent opioid modulation of neuronal calcium channels

21 January 2018

1 reference

Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels

21 January 2018

1 reference

Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels

21 January 2018

1 reference

RETRACTED: L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII.

21 January 2018

1 reference

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane

21 January 2018

1 reference

Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

21 January 2018

1 reference

Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis

21 January 2018

1 reference

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem

21 January 2018

1 reference

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

21 January 2018

1 reference

Direct inhibition of P/Q-type voltage-gated Ca 2+ channels by Gem does not require a direct Gem/Ca v β interaction

21 January 2018

1 reference

Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents

21 January 2018

1 reference

Essential Ca(V)beta modulatory properties are AID-independent

21 January 2018

1 reference

RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

21 January 2018

1 reference

Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release

21 January 2018

1 reference

RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels

21 January 2018

1 reference

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release

21 January 2018

1 reference

Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit.

21 January 2018

1 reference

The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6.

21 January 2018

1 reference

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

21 January 2018

1 reference

Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes

21 January 2018

1 reference

The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling

21 January 2018

1 reference

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization

21 January 2018

1 reference

Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel

21 January 2018

1 reference

Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle

21 January 2018

1 reference

The calcium channel alpha2/delta1 subunit is involved in extracellular signalling

21 January 2018

1 reference

Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit

21 January 2018

1 reference

Calcium channel diversity: multiple roles of calcium channel subunits

21 January 2018

1 reference

Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling

21 January 2018

1 reference

Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.

21 January 2018

1 reference

Proper restoration of excitation-contraction coupling in the dihydropyridine receptor beta1-null zebrafish relaxed is an exclusive function of the beta1a subunit

21 January 2018

1 reference

Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation.

21 January 2018

1 reference

The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing

21 January 2018

1 reference

Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse

21 January 2018

1 reference

Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels

21 January 2018

1 reference

Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function

21 January 2018

1 reference

Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels

21 January 2018

1 reference

The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.

21 January 2018

1 reference

Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory

21 January 2018

1 reference

Ca2+ channel-independent requirement for MAGUK family CACNB4 genes in initiation of zebrafish epiboly

21 January 2018

1 reference

Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons.

21 January 2018

1 reference

Robust pacemaking in substantia nigra dopaminergic neurons

21 January 2018

1 reference

Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses

21 January 2018

1 reference

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway

21 January 2018

1 reference

Protein structure prediction on the Web: a case study using the Phyre server

21 January 2018

1 reference

Ca2+ channel beta-subunits: structural insights AID our understanding

21 January 2018

1 reference

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

21 January 2018

1 reference

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells

21 January 2018

1 reference

α2δ expression sets presynaptic calcium channel abundance and release probability

31 March 2020

1 reference

Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

31 March 2020

1 reference

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

31 March 2020

1 reference

Gabapentin for drug-resistant partial epilepsy

31 March 2020

1 reference

Pregabalin for acute and chronic pain in adults

31 March 2020

1 reference

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

31 March 2020

1 reference

Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79

31 March 2020

1 reference

Unique modulation of L-type Ca2+ channels by short auxiliary beta1d subunit present in cardiac muscle

31 March 2020

1 reference

Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum

31 March 2020

1 reference

The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

31 March 2020

1 reference

Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene

31 March 2020

1 reference

12 December 2020

Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer

1 reference

12 December 2020

Direct alteration of the P/Q-type Ca2+ channel property by polyglutamine expansion in spinocerebellar ataxia 6.

1 reference

12 December 2020

Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides

1 reference

12 December 2020

Plant histidine kinases: an emerging picture of two-component signal transduction in hormone and environmental responses

1 reference

12 December 2020

Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different

1 reference

12 December 2020

3Hnitrendipine receptors in skeletal muscle

1 reference

12 December 2020

Calcium channel alpha(2)delta subunits-structure and Gabapentin binding

1 reference

12 December 2020

Identification of three subunits of the high affinity omega-conotoxin MVIIC-sensitive Ca2+ channel

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRN3311

1 reference

Dimensions Publication ID

1 August 2017

1011940556

0 references

1 reference