Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice (Q34286764)

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scientific article published on August 6, 2010

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English	Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice	scientific article published on August 6, 2010

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Europe PubMed Central

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1 August 2017

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice (English)

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Europe PubMed Central

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1 August 2017

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Arthur I Cederbaum

5

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Arthur I Cederbaum

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1 August 2017

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Yongke Lu

1

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1 August 2017

Defeng Wu

2

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1 August 2017

Xiaodong Wang

3

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1 August 2017

Stephen C. Ward

4

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18 June 2024

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18 June 2024

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6 August 2010

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1 August 2017

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20692331/pdf/?tool=EBI

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18 June 2024

https://europepmc.org/articles/PMC2975513

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20692331

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https://europepmc.org/articles/PMC2975513?pdf=render

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https://doi.org/10.1016/j.freeradbiomed.2010.07.026

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https://api.elsevier.com/content/article/PII:S0891584910004661?httpAccept=text/xml

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10.1016/J.FREERADBIOMED.2010.07.026

https://api.crossref.org/works/10.1016/J.FREERADBIOMED.2010.07.026

18 June 2024

https://api.elsevier.com/content/article/PII:S0891584910004661?httpAccept=text/plain

1 reference

10.1016/J.FREERADBIOMED.2010.07.026

https://api.crossref.org/works/10.1016/J.FREERADBIOMED.2010.07.026

18 June 2024

Free Radical Biology and Medicine

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Europe PubMed Central

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1 August 2017

49

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Europe PubMed Central

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1 August 2017

9

1 reference

Europe PubMed Central

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1 August 2017

1406-1416

1 reference

Europe PubMed Central

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1 August 2017

Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice

1 reference

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6 July 2018

Molecular mechanisms of alcoholic fatty liver

1 reference

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6 July 2018

Resveratrol alleviates alcoholic fatty liver in mice

1 reference

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6 July 2018

Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment

1 reference

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6 July 2018

Alcohol and lipid metabolism

1 reference

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6 July 2018

CYP2E1 and oxidative liver injury by alcohol

1 reference

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6 July 2018

Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1

1 reference

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6 July 2018

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

1 reference

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6 July 2018

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

1 reference

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6 July 2018

Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Diallyl sulfide induces heme oxygenase-1 through MAPK pathway

1 reference

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6 July 2018

Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death

1 reference

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6 July 2018

Oxidants and antioxidants in alcohol-induced liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Role of mitochondria in alcoholic liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Introduction-serial review: alcohol, oxidative stress and cell injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Cytokines in alcoholic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Implication of free radical mechanisms in ethanol-induced cellular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Ethanol toxicity and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

6 July 2018

The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model

1 reference

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28 October 2018

Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice

1 reference

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28 October 2018

Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice

1 reference

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28 October 2018

A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury

1 reference

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28 October 2018

Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice

1 reference

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28 October 2018

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis

1 reference

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Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model

1 reference

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28 October 2018

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

1 reference

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28 October 2018

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

1 reference

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28 October 2018

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

1 reference

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28 October 2018

Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

28 October 2018

Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

1 reference

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28 October 2018

Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation

1 reference

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28 October 2018

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1 reference

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28 October 2018

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

1 reference

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28 October 2018

Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation

1 reference

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28 October 2018

Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat.

1 reference

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28 October 2018

The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol.

1 reference

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28 October 2018

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole

1 reference

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28 October 2018

II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975513

28 October 2018

Apoptosis and bcl-2 protein expression in experimental alcoholic liver disease in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gadolinium chloride reduces cytochrome P450: Relevance to chemical-induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2E1 is not involved in early alcohol-induced liver injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of chronic ethanol toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP2E1 in the hepatotoxicity of acetaminophen

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new oral low-carbohydrate alcohol liquid diet producing liver lesions: a preliminary account

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PREVENTION OF THE ACUTE ETHANOL-INDUCED FATTY LIVER BY THE SIMULTANEOUS ADMINISTRATION OF ANTIOXIDANTS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive species in ischemic rat lung injury: contribution of peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/20692331

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.FREERADBIOMED.2010.07.026

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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