Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators (Q34271873)

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English	Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators (English)

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Europe PubMed Central

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1 August 2017

9

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Europe PubMed Central

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1 August 2017

Colleen M. Niswender

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Colleen M Niswender

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Europe PubMed Central

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1 August 2017

Craig W. Lindsley

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Craig W Lindsley

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Europe PubMed Central

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1 August 2017

P. Jeffrey Conn

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object named as

P Jeffrey Conn

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1 August 2017

Corey R. Hopkins

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object named as

Corey R Hopkins

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1 August 2017

2

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Eric S Dawson

1 reference

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1 August 2017

Mariusz Butkiewicz

4

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Mariusz Butkiewicz

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1 August 2017

author name string

Ralf Mueller

1

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1 August 2017

C David Weaver

6

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1 August 2017

publication date

17 May 2012

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1 August 2017

Journal of Molecular Modeling

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1 August 2017

18

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Europe PubMed Central

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1 August 2017

9

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Europe PubMed Central

PubMed publication ID

1 August 2017

4437-4446

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Europe PubMed Central

PubMed publication ID

1 August 2017

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats

1 reference

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Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

1 reference

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Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential

1 reference

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Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

1 reference

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Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

1 reference

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

1 reference

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Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

1 reference

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6 July 2018

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

1 reference

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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

1 reference

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

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Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

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(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

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Glutamate receptors and Parkinson's disease: opportunities for intervention

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Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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Identifiers

10.1007/S00894-012-1441-0

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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