Titin: properties and family relationships (Q34264712)

1 August 2017

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title

Titin: properties and family relationships (English)

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1 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14506471

13 March 2024

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13 March 2024

Larissa Tskhovrebova

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1 August 2017

John Trinick

series ordinal

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1 August 2017

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14506471

13 March 2024

publication date

1 September 2003

1 reference

full work available at URL

1 August 2017

https://www.nature.com/articles/nrm1198.pdf

file format

Portable Document Format

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https://www.nature.com/articles/nrm1198

13 March 2024

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Nature Reviews Molecular Cell Biology

13 March 2024

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

679-689

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New elastic protein from muscle

1 August 2017

cites work

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Titin: major myofibrillar components of striated muscle

31 March 2020

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Molecular size and shape of beta-connectin, an elastic protein of striated muscle

31 March 2020

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Purification and properties of native titin

31 March 2020

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Titin is an extraordinarily long, flexible, and slender myofibrillar protein

31 March 2020

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Visualization of the polarity of isolated titin molecules: a single globular head on a long thin rod as the M band anchoring domain?

31 March 2020

1 reference

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

31 March 2020

1 reference

Titins: giant proteins in charge of muscle ultrastructure and elasticity

31 March 2020

1 reference

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity

31 March 2020

1 reference

A 11.5-kb 5'-terminal cDNA sequence of chicken breast muscle connectin/titin reveals its Z line binding region

31 March 2020

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Molecular cloning of a partial cDNA clone encoding the C terminal region of chicken breast muscle connectin

31 March 2020

1 reference

Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans

31 March 2020

1 reference

Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set

31 March 2020

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Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity

31 March 2020

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The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains

31 March 2020

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Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin

31 March 2020

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Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.

31 March 2020

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Flexibility and extensibility in the titin molecule: analysis of electron microscope data

31 March 2020

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Modularity and homology: modelling of the type II module family from titin

31 March 2020

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Modularity and homology: modelling of the titin type I modules and their interfaces

31 March 2020

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The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity

31 March 2020

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Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin.

31 March 2020

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Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms.

31 March 2020

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Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs

31 March 2020

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Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.

31 March 2020

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Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin

31 March 2020

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Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

31 March 2020

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Interaction between titin and thin filaments in intact cardiac muscle

31 March 2020

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A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy

31 March 2020

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Identification of new repeating motifs in titin

31 March 2020

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Modular motif, structural folds and affinity profiles of the PEVK segment of human fetal skeletal muscle titin

31 March 2020

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Polyproline II helix is a key structural motif of the elastic PEVK segment of titin

31 March 2020

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Myosin rod-packing schemes in vertebrate muscle thick filaments

31 March 2020

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Differential expression of cardiac titin isoforms and modulation of cellular stiffness

31 March 2020

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Titin and the sarcomere symmetry paradox.

31 March 2020

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Muscle thick filaments are rigid coupled tubules, not flexible ropes

31 March 2020

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Structural and functional studies of titin’s fn3 modules reveal conserved surface patterns and binding to myosin S1 - a possible role in the frank-starling mechanism of the heart

31 March 2020

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Does titin regulate the length of muscle thick filaments?

31 March 2020

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Thick filament assembly occurs after the formation of a cytoskeletal scaffold.

31 March 2020

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A physiological role for titin and nebulin in skeletal muscle

31 March 2020

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Cardiac titin: an adjustable multi-functional spring

31 March 2020

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Titin folding energy and elasticity

31 March 2020

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Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin

31 March 2020

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Nature of PEVK-titin elasticity in skeletal muscle

31 March 2020

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PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10

31 March 2020

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Extensibility of isoforms of cardiac titin: variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity

31 March 2020

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Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils

31 March 2020

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Folding-unfolding transitions in single titin molecules characterized with laser tweezers.

31 March 2020

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Elasticity and unfolding of single molecules of the giant muscle protein titin

31 March 2020

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Multiple conformations of PEVK proteins detected by single-molecule techniques

31 March 2020

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Molecular mechanics of cardiac titin's PEVK and N2B spring elements.

31 March 2020

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Reversible unfolding of individual titin immunoglobulin domains by AFM

31 March 2020

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Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently

31 March 2020

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Reverse engineering of the giant muscle protein titin

31 March 2020

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Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

31 March 2020

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Sarcomeric visco-elasticity of chemically skinned skeletal muscle fibres of the rabbit at rest

31 March 2020

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A survey of in situ sarcomere extension in mouse skeletal muscle

31 March 2020

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The effect of core destabilization on the mechanical resistance of I27.

31 March 2020

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Hidden complexity in the mechanical properties of titin

31 March 2020

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Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system

31 March 2020

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Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

31 March 2020

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Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

31 March 2020

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Structural basis for activation of the titin kinase domain during myofibrillogenesis

31 March 2020

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Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions

31 March 2020

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Association of titin and myosin heavy chain in developing skeletal muscle

31 March 2020

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Dynamics of actin and assembly of connectin (titin) during myofibrillogenesis in embryonic chick cardiac muscle cells in vitro

31 March 2020

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Organization of connectin/titin filaments in sarcomeres of differentiating chicken skeletal muscle cells

31 March 2020

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Constitutive and variable regions of Z-disk titin/connectin in myofibril formation: a dominant-negative screen

31 March 2020

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Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein

31 March 2020

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Titin-cap associates with, and regulates secretion of, Myostatin

31 March 2020

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The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin

31 March 2020

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Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

31 March 2020

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Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

31 March 2020

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Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin

31 March 2020

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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

31 March 2020

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Titin mutations as the molecular basis for dilated cardiomyopathy

31 March 2020

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Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

31 March 2020

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The muscular dystrophy with myositis (mdm) mouse mutation disrupts a skeletal muscle-specific domain of titin

31 March 2020

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Requirements of Kettin, a giant muscle protein highly conserved in overall structure in evolution, for normal muscle function, viability, and flight activity of Drosophila

31 March 2020

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Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans

31 March 2020

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D-Titin: a giant protein with dual roles in chromosomes and muscles

31 March 2020

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Invertebrate connectin spans as much as 3.5 microm in the giant sarcomeres of crayfish claw muscle

31 March 2020

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Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family

31 March 2020

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Alternative splicing of an amino-terminal PEVK-like region generates multiple isoforms of Drosophila projectin.

31 March 2020

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Kettin, a major source of myofibrillar stiffness in Drosophila indirect flight muscle

31 March 2020

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Association of kettin with actin in the Z-disc of insect flight muscle

31 March 2020

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Projectin is an invertebrate connectin (titin): isolation from crayfish claw muscle and localization in crayfish claw muscle and insect flight muscle

31 March 2020

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Mini-titins in striated and smooth molluscan muscles: structure, location and immunological crossreactivity.

31 March 2020

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Connectin, giant elastic protein, in giant sarcomeres of crayfish claw muscle.

31 March 2020

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Isolation and characterization of a kettin-like protein from crayfish claw muscle.

31 March 2020

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Direct visualization of extensibility in isolated titin molecules

31 March 2020

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The molecular organization of myosin in stress fibers of cultured cells

31 March 2020

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Periodic organization of the contractile apparatus in smooth muscle revealed by the motion of dense bodies in single cells

31 March 2020

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Human autoantibodies reveal titin as a chromosomal protein

31 March 2020

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Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle

31 March 2020

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Identification and characterization of two huge protein components of the brush border cytoskeleton: evidence for a cellular isoform of titin

31 March 2020

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Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro

31 March 2020

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Smitin, a novel smooth muscle titin-like protein, interacts with myosin filaments in vivo and in vitro

31 March 2020

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The filament lattice of striated muscle

31 March 2020

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M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression

31 March 2020

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The spectrin repeat: a structural platform for cytoskeletal protein assemblies

31 March 2020

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Flexibility and Fine Structure of Smooth‐Muscle α‐Actinin

31 March 2020

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The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains

31 March 2020

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Towards a complete atomic structure of spectrin family proteins

31 March 2020

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Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles

31 March 2020

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Mechanical unfolding of single filamin A (ABP-280) molecules detected by atomic force microscopy

31 March 2020

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Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans

31 March 2020

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Structurally differentDrosophila striated muscles utilize distinct variants of Z-band-associated proteins

31 March 2020

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Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

31 March 2020

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Electron microscopic filament lengths of connection and its fragments

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Towards a molecular understanding of titin

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Purification and physical properties of nematode mini-titins and their relation to twitchin

13 March 2024

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Symposia of the Society for Experimental Biology

13 March 2024

116

167

KT Vaughan

1992

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13 March 2024

Identifiers

DOI

10.1038/NRM1198

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Dimensions Publication ID

1 August 2017

1006659069

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