First-pass elimination. Basic concepts and clinical consequences (Q34257205)

31 July 2017

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title

First-pass elimination. Basic concepts and clinical consequences (English)

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31 July 2017

Pond SM

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31 July 2017

Tozer TN

series ordinal

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31 July 2017

publication date

1 January 1984

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Clinical Pharmacokinetics

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

1-25

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Enhancement of the bioavailability of propranolol and metoprolol by food

31 July 2017

cites work

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12 December 2020

Effect of phenytoin on meperidine clearance and normeperidine formation

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12 December 2020

Pharmacokinetics of oxprenolol in normal subjects

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12 December 2020

Degradation of porstaglandin F2alpha in the human pulmonary circulation

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12 December 2020

Dose-dependent drug metabolism during the absorptive phase

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12 December 2020

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

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12 December 2020

Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration

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12 December 2020

Inhibition of propranolol metabolism by chlorpromazine

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12 December 2020

Dose-dependent kinetics of quinidine in the perfused rat liver preparation. Kinetics of formation of active metabolites

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12 December 2020

Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.

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12 December 2020

Sodium salicylamide: Relative bioavailability and subjective effects

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12 December 2020

Systemic availability of orally administered meperidine

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12 December 2020

The pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses

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12 December 2020

Rectal drug administration: clinical pharmacokinetic considerations

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12 December 2020

Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol

1 reference

12 December 2020

First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma

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12 December 2020

Dihydroergotamine increases the bioavailability of orally administered etilefrine

1 reference

12 December 2020

Plasma propranolol levels in adults With observations in four children

1 reference

12 December 2020

Pharmacokinetics of zimelidine in humans--plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine

1 reference

12 December 2020

Effect of food on the bioavailability of labetalol

1 reference

12 December 2020

Verapamil kinetics in normal subjects and patients with coronary artery spasm

1 reference

12 December 2020

Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man.

1 reference

12 December 2020

First-pass effect of nalorphine in rats

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12 December 2020

Relative effectiveness of nitroglycerin ointment according to site of application

1 reference

12 December 2020

Nitroglycerin Pharmacokinetics After Intravenous Infusion in Normal Subjects

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12 December 2020

Liver circulation and function

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12 December 2020

Interaction between oral propranolol and hydralazine

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12 December 2020

Metabolism of isoprenaline in dog and man

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12 December 2020

beta-blocker plasma concentrations and inflammatory disease: clinical implications

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12 December 2020

Influence of route of administration on drug availability

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12 December 2020

Drugs as indicators of hepatic function.

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12 December 2020

Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver

1 reference

12 December 2020

Absolute quinidine bioavailability

1 reference

12 December 2020

First-pass effect after rectal administration of thiazinamium methylsulfate

1 reference

12 December 2020

Pharmacokinetics of chlormethiazole in humans

1 reference

12 December 2020

Rectal bioavailability of lidocaine in man: Partial avoidance of “first-pass” metabolism

1 reference

12 December 2020

Effects of inflammatory disease on plasma oxprenolol concentrations

1 reference

12 December 2020

d-Propoxyphene kinetics after single oral and intravenous doses in man

1 reference

12 December 2020

Interactions of phenobarbital with propranolol in the dog. 1. Plasma protein binding

1 reference

12 December 2020

Meperidine disposition in man: Influence of urinary pH and route of administration

1 reference

12 December 2020

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

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12 December 2020

Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function

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12 December 2020

Ranitidine bioavailability and kinetics in normal male subjects

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12 December 2020

First-pass metabolism of imipramine in man

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12 December 2020

Effect of route of administration on the relationship between -adrenergic blockade and plasma propranolol level.

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12 December 2020

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

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12 December 2020

Clinical pharmacokinetics of hydralazine

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12 December 2020

Surgical catheterization of heptic-portal and peripheral circulations and maintenance in pharmacokinetic studies

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12 December 2020

Amitriptyline disposition in young and elderly normal men

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12 December 2020

The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration

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12 December 2020

Bioavailability and saturation of the presystemic metabolism of oral lorcainide therapy initiated in three different dose regimens

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12 December 2020

Verapamil disposition kinetics in chronic atrial fibrillation

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12 December 2020

Influence of pentobarbital on metoprolol plasma levels

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12 December 2020

Morphine kinetics in cancer patients

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12 December 2020

Plethysmographic comparison of sublingual and intramuscular ergotamine

1 reference

12 December 2020

Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes

1 reference

12 December 2020

Stereoselective disposition and glucuronidation of propranolol in humans

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12 December 2020

Morphine metabolism in man

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12 December 2020

Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis

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12 December 2020

Biological determinants of propranolol disposition in man

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12 December 2020

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil

1 reference

12 December 2020

Enhanced bioavailability of pethidine and pentazocine in patients with cirrhosis of the liver

1 reference

12 December 2020

Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil.

1 reference

12 December 2020

Clinical pharmacology and antiarrhythmic efficacy of encainide in patients with chronic ventricular arrhythmias

1 reference

12 December 2020

Low oral bioavailability of dihydroergotamine and first-pass extraction in patients with orthostatic hypotension

1 reference

12 December 2020

Systemic availability of ergotamine tartrate after oral, rectal and intramuscular administration

1 reference

12 December 2020

Prediction of steady-state verapamil plasma concentrations in children and adults.

1 reference

12 December 2020

Lorcainide; II. Plasma concentration-effect relationship

1 reference

12 December 2020

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

1 reference

12 December 2020

Single and multiple dose pharmacokinetics of oral quinidine sulfate and gluconate

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12 December 2020

Decreased first-pass metabolism of labetalol in chronic liver disease

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Oxidation phenotype--a major determinant of metoprolol metabolism and response

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12 December 2020

The disposition of propranolol. I. Elimination during oral absorption in man

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12 December 2020

Factors affecting the absorption of riboflavin in man.

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12 December 2020

Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt

1 reference

12 December 2020

Effect of cirrhosis of the liver on the pharmacokinetics of chlormethiazole

1 reference

12 December 2020

Antiarrhythmic activity of the O-demethyl metabolite of encainide

1 reference

12 December 2020

The metabolism of salbutamol in man.

1 reference

12 December 2020

Quinidine pharmacokinetics in man: choice of a disposition model and absolute bioavailability studies

1 reference

12 December 2020

Pharmacokinetics of papaverine hydrochloride and the biopharmaceutics of its oral dosage forms

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12 December 2020

First pass uptake of 14C-propranolol by the lung

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12 December 2020

Combined pharmacokinetic and pharmacodynamic studies on alprenolol and 4-hydroxy-alprenolol in man.

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12 December 2020

Comparison of intravenous and oral verapamil dosing

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12 December 2020

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1 reference

12 December 2020

Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer

1 reference

12 December 2020

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

12 December 2020

Propoxyphene and norpropoxyphene kinetics after single and repeated doses of propoxyphene

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12 December 2020

Clearance concepts in pharmacokinetics

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12 December 2020

Interactions of phenobarbital with propranolol in the dog. 2. Bioavailability, metabolism and pharmacokinetics

1 reference

12 December 2020

Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients

1 reference

12 December 2020

Hepatic First-pass Metabolism in Liver Disease

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12 December 2020

Lorcainide disposition kinetics in arrhythmia patients

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12 December 2020

Clinical pharmacokinetics of metoprolol

1 reference

12 December 2020

Noninvasive assessment of portal-systemic shunting: evaluation of a method to investigate systemic availability of oral glyceryl trinitrate by digital plethysmography.

1 reference

12 December 2020

Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.

1 reference

12 December 2020

Presystemic metabolism of meperidine to normeperidine in normal and cirrhotic subjects

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12 December 2020

Proscillaridin activity in portal and peripheral venous blood after oral administration to man

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12 December 2020

Effect of dose size on the pharmacokinetics of oral hydrocortisone suspension

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12 December 2020

The predictable relationship between plasma levels and dose during chronic propranolol therapy

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12 December 2020

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

1 reference

12 December 2020

First-pass metabolism of nortriptyline in man

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12 December 2020

Sublingual and Oral Administration of Methyltestosterone. A Comparison of Drug Bioavailability

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12 December 2020

On the pharmacokinetics of phenacetin in man

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12 December 2020

Influence of Food Intake on Presystemic Clearance of Drugs

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12 December 2020

Isolated perfused rabbit lung as a model for intravascular and intrabronchial administration of bronchodilator drugs I:Isoproterenol

1 reference

12 December 2020

Pharmacokinetics of lidocaine in man

1 reference

12 December 2020

Decreased Concentration of Phenacetin in Plasma of Cigarette Smokers

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12 December 2020

4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol

1 reference

12 December 2020

Rapid disappearance of nitroglycerin following incubation with human blood

1 reference

12 December 2020

Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient

1 reference

12 December 2020

Influence of pentobarbital on effect and plasma levels of alprenolol and 4-hydroxy-alprenolol

1 reference

12 December 2020

Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol

1 reference

12 December 2020

A pharmacokinetic study of neostigmine in man using gas chromatography-mass spectrometry

1 reference

12 December 2020

Propranolol disposition in chronic liver disease: a physiological approach

1 reference

12 December 2020

Codeine kinetics as determined by radioimmunoassay

1 reference

12 December 2020

Pharmacokinetics of methotrimeprazine after single and multiple doses

1 reference

12 December 2020

Metabolism of isoprenaline after aerosol and direct intrabronchial administration in man and dog.

1 reference

12 December 2020

Direct determination of hepatic extraction of verapamil in cardiac patients

1 reference

12 December 2020

Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long-term dosing

1 reference

12 December 2020

Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man

1 reference

12 December 2020

Food-induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites

1 reference

12 December 2020

Effect of pentobarbital on the disposition of alprenolol

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12 December 2020

Lorcainide; I. Saturable presystemic elimination

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12 December 2020

Effects of smoking and chronic hepatitis B on lidocaine and indocyanine green kinetics

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12 December 2020

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ pr

1 reference

12 December 2020

Contribution of 4-hydroxy-alprenolol to adrenergic beta receptor blockade of alprenolol

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12 December 2020

Pentazocine and tripelennamine (T's and Blues) abuse: toxicological findings in 39 cases

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12 December 2020

Plasma Isosorbide Dinitrate Concentrations in Human Subjects after Administration of Standard and Sustained-Release Formulations

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12 December 2020

Disposition of naloxone-7,8,3H in normal and narcotic-dependent men

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12 December 2020

Metabolism of flurazepam by the small intestine

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12 December 2020

Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure

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12 December 2020

First-pass effect of morphine in rats

1 reference

12 December 2020

Reduced verapamil clearance during long-term oral administration

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12 December 2020

Nortriptyline formation after single oral and intramuscular doses of amitriptyline

1 reference

12 December 2020

Studies on hydralazine. III. Bioavailability of hydralazine in man

1 reference

12 December 2020

Clinical pharmacokinetics of pethidine: 1982.

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12 December 2020

Active metabolites of imipramine and desipramine in man

1 reference

12 December 2020

Kinetics of Acetylsalicylic Acid Disposition in Man

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12 December 2020

Drug Metabolism by the Gastrointestinal Mucosa

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12 December 2020

Bioavailability and first-pass metabolism of oral pentazocine in man

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12 December 2020

10.2165/00003088-198409010-00001

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1025612113

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Fatcat ID

release_tx7u77vxizga7labxkkapawlee

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Fatcat

https://api.fatcat.wiki/v0/release/tx7u77vxizga7labxkkapawlee

24 November 2022

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