Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer. (Q34186022)

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12 March 2020

title

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer (English)

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G protein-coupled receptor

12 March 2020

main subject

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Antoni Cortés

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Xavier Guitart

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Gemma Navarro

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Estefania Moreno

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Ning-Sheng Cai

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Marta Sánchez-Soto

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Sandeep Kumar-Barodia

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Yamini T Naidu

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Josefa Mallol

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Carme Lluís

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Vicent Casadó

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publication date

5 August 2014

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12 March 2020

published in

Molecular Pharmacology

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volume

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issue

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page(s)

417-429

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Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

12 March 2020

cites work

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G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives

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The prevalence, maintenance, and relevance of G protein-coupled receptor oligomerization

5 July 2018

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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

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Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain

5 July 2018

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CODA-RET reveals functional selectivity as a result of GPCR heteromerization

5 July 2018

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Asymmetry of GPCR oligomers supports their functional relevance.

5 July 2018

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Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

5 July 2018

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Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices

5 July 2018

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Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer

5 July 2018

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Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways

5 July 2018

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Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function.

5 July 2018

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5 July 2018

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Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

5 July 2018

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Building a new conceptual framework for receptor heteromers

5 July 2018

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Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization

5 July 2018

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

5 July 2018

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Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

5 July 2018

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Detection of heteromerization of more than two proteins by sequential BRET-FRET.

5 July 2018

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Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

5 July 2018

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Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities

5 July 2018

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5 July 2018

https://pubmed.ncbi.nlm.nih.gov/25097189

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

1 reference

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5 July 2018

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The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

28 October 2018

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Selective Inhibition of Adenylyl Cyclase Type V by the Dopamine D3Receptor

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25097189

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12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.114.093096

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12 March 2020

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12 March 2020

PubMed publication ID

25097189

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