Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice (Q34179450)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21505263%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice (English)

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29 January 2020

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29 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21505263%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Joël Prémont

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29 January 2020

Andre Mann

series ordinal

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29 January 2020

Christoph Kellendonk

series ordinal

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29 January 2020

Didier Rognan

series ordinal

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29 January 2020

language of work or name

English

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publication date

18 April 2011

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Journal of Clinical Investigation

29 January 2020

published in

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29 January 2020

volume

121

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29 January 2020

issue

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29 January 2020

page(s)

1846-1857

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

29 January 2020

cites work

1 reference

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Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice

28 July 2018

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Short- and long-term effects of intermittent social defeat stress on brain-derived neurotrophic factor expression in mesocorticolimbic brain regions

28 July 2018

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The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

28 July 2018

1 reference

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The when and where of BDNF and the antidepressant response

28 July 2018

1 reference

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BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?

28 July 2018

1 reference

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New insights into BDNF function in depression and anxiety

28 July 2018

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Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse

28 July 2018

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Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening

28 July 2018

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A neurotrophic model for stress-related mood disorders

28 July 2018

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Assessing the scaffold diversity of screening libraries

28 July 2018

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Between a rock and a hard place?

28 July 2018

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

28 July 2018

1 reference

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BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis

28 July 2018

1 reference

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Virtual screening of chemical libraries

28 July 2018

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Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

28 July 2018

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Molecular basis of neurotrophin-receptor interactions.

28 July 2018

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A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

28 July 2018

1 reference

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Assessing antidepressant activity in rodents: recent developments and future needs

28 July 2018

1 reference

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Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5

28 July 2018

1 reference

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Neurotrophin signal transduction in the nervous system

28 July 2018

1 reference

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A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat.

28 July 2018

1 reference

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Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer

28 July 2018

1 reference

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p75 and Trk: a two-receptor system

28 July 2018

1 reference

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A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy

28 July 2018

1 reference

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The use of a plus-maze to measure anxiety in the mouse

28 July 2018

1 reference

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PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor

28 July 2018

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Behavioral despair in mice: a primary screening test for antidepressants

28 July 2018

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A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

28 July 2018

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A new nerve growth factor-mimetic peptide active on neuropathic pain in rats

28 October 2018

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Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions

28 October 2018

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T-maze alternation in the rodent

28 October 2018

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

28 October 2018

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BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal

28 October 2018

1 reference

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Social threat and novel cage stress-induced sustained extracellular-regulated kinase1/2 (ERK1/2) phosphorylation but differential modulation of brain-derived neurotrophic factor (BDNF) expression in the hippocampus of NMRI mice

28 October 2018

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Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

28 October 2018

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Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".

28 October 2018

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Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

28 October 2018

1 reference

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Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression

28 October 2018

1 reference

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Neurotrophin receptor structure and interactions

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083767

A fast flexible docking method using an incremental construction algorithm.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083767

Synthesis and amnesia-reversal activity of a series of 7- and 5-membered 3-acylamino lactams

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083767

The interplay of learning and anxiety in the elevated plus-maze

28 October 2018

1 reference

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A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety

28 October 2018

1 reference

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Pharmacological estimation of drug-receptor dissociation constants. Statistical evaluation. I. Agonists

28 October 2018

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12 December 2020

The tail suspension test: a new method for screening antidepressants in mice

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12 December 2020

Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice

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12 December 2020

Emerging themes in structural biology of neurotrophic factors

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12 December 2020

Cell death in regenerating populations of neurons in BDNF mutant mice

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12 December 2020

Identifiers

DOI

10.1172/JCI43992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21505263%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21505263%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

21505263

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21505263%20AND%20SRC:MED&resulttype=core&format=json