Endogenous kynurenines as targets for drug discovery and development (Q34156448)

31 July 2017

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title

Endogenous kynurenines as targets for drug discovery and development (English)

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31 July 2017

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Trevor W Stone

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L Gail Darlington

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31 July 2017

publication date

1 August 2002

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

609-620

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Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

31 July 2017

cites work

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Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

31 March 2020

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An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

31 March 2020

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Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway

31 March 2020

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Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

31 March 2020

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Growth inhibition of multiresistant enterococci by interferon-gamma-activated human uro-epithelial cells

31 March 2020

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Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects

31 March 2020

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Glutamate antagonists limit tumor growth

31 March 2020

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Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes

31 March 2020

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Prevention of allogeneic fetal rejection by tryptophan catabolism

31 March 2020

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Inhibition of nitric oxide synthase expression and activity in macrophages by 3-hydroxyanthranilic acid, a tryptophan metabolite

31 March 2020

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Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection

31 March 2020

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Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

31 March 2020

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Kynurenic acid influences the respiratory parameters of rat heart mitochondria

31 March 2020

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In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum

31 March 2020

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Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl

31 March 2020

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Quinolinate neurotoxicity in cortical cell culture

31 March 2020

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Neurotoxic effect induced by quinolinic acid in dissociated cell culture of mouse hippocampus

31 March 2020

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Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

31 March 2020

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Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex

31 March 2020

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3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum

31 March 2020

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Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration

31 March 2020

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Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists

31 March 2020

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Apoptosis in the in vivo mammalian forebrain

31 March 2020

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Morphogen gradient interpretation

31 March 2020

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Effect of dexamethasone treatment on maturational changes in the NMDA receptor in sheep brain

31 March 2020

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Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells

31 March 2020

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Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

31 March 2020

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Temporal and spatial changes of quinolinic acid immunoreactivity in the immune system of lipopolysaccharide-stimulated mice

31 March 2020

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Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

31 March 2020

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Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.

31 March 2020

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Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region

31 March 2020

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Metabolism of [5‐3H]Kynurenine in the Rat Brain In Vivo: Evidence for the Existence of a Functional Kynurenine Pathway

31 March 2020

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Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

31 March 2020

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Maternal, umbilical, and amniotic fluid concentrations of tryptophan and kynurenine after labor or cesarean section

31 March 2020

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Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading

31 March 2020

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Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor

31 March 2020

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Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

31 March 2020

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Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices

31 March 2020

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Modulation and function of kynurenic acid in the immature rat brain

31 March 2020

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Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices

31 March 2020

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Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist

31 March 2020

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Presynaptic kynurenate-sensitive receptors inhibit glutamate release

31 March 2020

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The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

31 March 2020

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Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons

31 March 2020

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The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

31 March 2020

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31 March 2020

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Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia

31 March 2020

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Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

31 March 2020

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Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

31 March 2020

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Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

31 March 2020

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GABA and GABAA receptor changes in the substantia nigra of the rat following quinolinic acid lesions in the striatum closely resemble Huntington's disease

31 March 2020

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3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

31 March 2020

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Increase in kynurenic acid in Huntington's disease motor cortex

31 March 2020

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Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

31 March 2020

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Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases

31 March 2020

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Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

31 March 2020

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Early kynurenergic impairment in Huntington's disease and in a transgenic animal model

31 March 2020

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Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

31 March 2020

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Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice

31 March 2020

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Tryptophan degradation and immune activation in Alzheimer's disease.

31 March 2020

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Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome

31 March 2020

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Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.

31 March 2020

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Neuroactive kynurenines in Lyme borreliosis

31 March 2020

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Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil

31 March 2020

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Temporal and spatial changes of quinolinic acid immunoreactivity in the gerbil hippocampus following transient cerebral ischemia

31 March 2020

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Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig

31 March 2020

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Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans.

31 March 2020

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Increased kynurenic acid in the brain after neonatal asphyxia

31 March 2020

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Neonatal asphyxia in rats: acute effects on cerebral kynurenine metabolism

31 March 2020

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Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway

31 March 2020

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A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: II. Correlations with psychopathology.

31 March 2020

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Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia

31 March 2020

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Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis

31 March 2020

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Central nervous system activation of the indoleamine-2,3-dioxygenase pathway in human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

31 March 2020

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Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor

31 March 2020

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4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex

31 March 2020

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Neuroprotective effects of RPR 104632, a novel antagonist at the glycine site of the NMDA receptor, in vitro.

31 March 2020

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Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures

31 March 2020

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Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies

31 March 2020

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Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid

31 March 2020

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Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo

31 March 2020

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In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum

31 March 2020

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Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus

31 March 2020

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Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity

31 March 2020

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Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia

31 March 2020

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(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats

31 March 2020

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Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase

31 March 2020

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Pyrrolo[3,2-c]quinoline derivatives: a new class of kynurenine-3-hydroxylase inhibitors

31 March 2020

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4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase

31 March 2020

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Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase

31 March 2020

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A comparative study on the inhibition of human and bacterial kynureninase by novel bicyclic kynurenine analogues.

31 March 2020

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4-Halo-3-hydroxyanthranilic acids: Potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro

31 March 2020

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Effects of the 3-hydroxyanthranilic acid analogue NCR-631 on anoxia-, IL-1 beta- and LPS-induced hippocampal pyramidal cell loss in vitro

31 March 2020

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Glutamate signalling in non-neuronal tissues

31 March 2020

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Differential expression of glutamate receptor subtypes in rat pancreatic islets

31 March 2020

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Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection

31 March 2020

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3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†

31 March 2020

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Control of extracellular matrix degradation by interferon-gamma. The tryptophan connection

31 March 2020

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The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus

31 March 2020

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Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.

31 March 2020

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Specific antagonists of NMDA receptors prevent osteoclast sealing zone formation required for bone resorption

31 March 2020

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Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity

31 March 2020

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Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine

31 March 2020

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The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

31 March 2020

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Cardiovascular actions of kynuramine and 5-hydroxykynuramine in pithed rats

31 March 2020

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5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats

31 March 2020

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Autoradiographic localization of tryptamine binding sites in the rat and dog central nervous system.

31 March 2020

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N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis

31 March 2020

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Melatonin, 5-methoxytryptamine and some of their analogs as cyclo-oxygenase inhibitors in rat medial basal hypothalamus

31 March 2020

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Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex

31 March 2020

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Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives

31 March 2020

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Clinical experiences with the use of indole-3-pyruvic acid.

31 March 2020

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Tryptophan Nutrition and Metabolism: An Overview

31 March 2020

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7 January 2021

Energetic Dysfunction in Quinolinic Acid‐Lesioned Rat Striatum

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7 January 2021

Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys

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7 January 2021

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity

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7 January 2021

Identifiers

DOI

10.1038/NRD870

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Dimensions Publication ID

31 July 2017

1000453010

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