Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism (Q34144158)

31 July 2017

title

Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism (English)

1 reference

31 July 2017

M Perola

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E Boerwinkle

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ORCID Public Data File 2021

31 July 2017

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author name string

S M Fullerton

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31 July 2017

A G Clark

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31 July 2017

K M Weiss

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31 July 2017

D A Nickerson

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31 July 2017

S L Taylor

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31 July 2017

J H Stengârd

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31 July 2017

V Salomaa

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31 July 2017

E Vartiainen

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31 July 2017

C F Sing

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31 July 2017

language of work or name

English

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publication date

13 September 2000

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American Journal of Human Genetics

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

881-900

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EVOLUTION IN MENDELIAN POPULATIONS

31 July 2017

cites work

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Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene

5 July 2018

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SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease

5 July 2018

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Genetic drift in an infinite population. The pseudohitchhiking model

5 July 2018

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Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus

5 July 2018

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Evidence for variable selective pressures at MC1R

5 July 2018

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Recombinational and mutational hotspots within the human lipoprotein lipase gene

5 July 2018

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APOE alleles and lipophylic pathogens

5 July 2018

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The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms

5 July 2018

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5 July 2018

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Spatial and temporal distribution of the neutral polymorphisms in the last ZFX intron: analysis of the haplotype structure and genealogy

5 July 2018

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DNA sequence variation in a non-coding region of low recombination on the human X chromosome

5 July 2018

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High polymorphism at the human melanocortin 1 receptor locus

5 July 2018

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5 July 2018

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5 July 2018

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Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

5 July 2018

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A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E.

5 July 2018

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Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.

5 July 2018

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Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease

5 July 2018

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Genetic structure of the ancestral population of modern humans

5 July 2018

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Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase

5 July 2018

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DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

5 July 2018

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Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

5 July 2018

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Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent

5 July 2018

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Statistical Tests of Neutrality of Mutations Against Population Growth, Hitchhiking and Background Selection

5 July 2018

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High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa.

5 July 2018

1 reference

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Archaic African and Asian lineages in the genetic ancestry of modern humans

5 July 2018

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Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease

5 July 2018

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The apolipoprotein E polymorphism in Greenland Inuit in its global perspective

5 July 2018

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

5 July 2018

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Mitochondrial portraits of human populations using median networks

5 July 2018

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Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.

5 July 2018

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Properties of statistical tests of neutrality for DNA polymorphism data

5 July 2018

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Statistical tests of neutrality of mutations

5 July 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

5 July 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

5 July 2018

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Apolipoprotein E: structure-function relationships

5 July 2018

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Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

5 July 2018

1 reference

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

5 July 2018

1 reference

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Protection against Alzheimer's disease with apoE epsilon 2.

5 July 2018

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Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels

5 July 2018

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Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.

5 July 2018

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Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease

5 July 2018

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Apolipoprotein E polymorphism in Italy investigated in native plasma by a simple polyacrylamide gel isoelectric focusing technique. Comparison with frequency data of other European populations

5 July 2018

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Haemostatic factors and lipoprotein (a) in three geographical areas in Finland: the Finrisk Haemostasis Study.

5 July 2018

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Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

5 July 2018

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Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation

5 July 2018

1 reference

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A test of neutral molecular evolution based on nucleotide data

5 July 2018

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5 July 2018

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5 July 2018

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The "hitchhiking effect" revisited

5 July 2018

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Statistical method for testing the neutral mutation hypothesis by DNA polymorphism

5 July 2018

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5 July 2018

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5 July 2018

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Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health

5 July 2018

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5 July 2018

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Studies of three Amerindian populations using nuclear DNA polymorphisms

5 July 2018

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The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants

5 July 2018

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On the number of segregating sites in genetical models without recombination

5 July 2018

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Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

5 July 2018

1 reference

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Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?

5 July 2018

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Haplotype analysis of the apolipoprotein E and apolipoprotein C1 loci in Portugal and São Tomé e Príncipe (Gulf of Guinea): linkage disequilibrium evidence that APOE*4 is the ancestral APOE allele.

28 October 2018

1 reference

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Sequence variation in the human angiotensin converting enzyme

28 October 2018

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The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.

28 October 2018

1 reference

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The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.

28 October 2018

1 reference

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Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1287893

Apolipoprotein E polymorphism in elderly east Africans

28 October 2018

1 reference

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The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics

28 October 2018

1 reference

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A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

28 October 2018

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A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

28 October 2018

1 reference

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Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

28 October 2018

1 reference

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Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes?

28 October 2018

1 reference

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Population genetics of apolipoprotein A-4, E, and H polymorphisms in Yanomami Indians of northwestern Brazil: associations with lipids, lipoproteins, and carbohydrate metabolism.

28 October 2018

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Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease.

28 October 2018

1 reference

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Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians

28 October 2018

1 reference

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Low nucleotide diversity in man

28 October 2018

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Man's place in Hominoidea revealed by mitochondrial DNA genealogy

28 October 2018

1 reference

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Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys

28 October 2018

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12 December 2020

A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele

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12 December 2020

Apolipoprotein B and E genetic polymorphisms in the Cayapa Indians of Ecuador

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12 December 2020

The baboon apolipoprotein E gene: Structure, expression, and linkage with the gene for apolipoprotein C-I

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12 December 2020

Apolipoprotein E polymorphism and atherosclerosis

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12 December 2020

Human apolipoprotein E. The complete amino acid sequence

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12 December 2020

Pattern of gradient of apolipoprotein E allele *4 frequencies in western Europe

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12 December 2020

A methylated CpG island 3' in the apolipoprotein-E gene does not repress its transcription

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12 December 2020

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study

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12 December 2020

Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E

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12 December 2020

Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men

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12 December 2020

Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age

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12 December 2020

Identifiers

DOI

10.1086/303070

1 reference

31 July 2017

1 reference

31 July 2017

1 reference