Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. (Q34109816)

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19 January 2020

title

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains (English)

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19 January 2020

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19 January 2020

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19 January 2020

Nicolas Siaud

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19 January 2020

Maria A Barbera

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19 January 2020

Akinori Egashira

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19 January 2020

Nicole Christ

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19 January 2020

Bing Xia

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19 January 2020

Maria Jasin

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19 January 2020

publication date

15 December 2011

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19 January 2020

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19 January 2020

volume

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19 January 2020

issue

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19 January 2020

page(s)

e1002409

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Creative Commons Attribution 4.0 International

19 January 2020

start time

15 December 2011

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Structural basis for recruitment of BRCA2 by PALB2

5 July 2018

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The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

5 July 2018

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Nucleases and helicases take center stage in homologous recombination

5 July 2018

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

5 July 2018

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The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

5 July 2018

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PALB2 links BRCA1 and BRCA2 in the DNA-damage response

5 July 2018

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DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA.

5 July 2018

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A syngeneic variance library for functional annotation of human variation: application to BRCA2

5 July 2018

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Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

5 July 2018

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Mechanism of eukaryotic homologous recombination

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Resistance to therapy caused by intragenic deletion in BRCA2

5 July 2018

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

5 July 2018

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Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

5 July 2018

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Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

5 July 2018

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

5 July 2018

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Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

5 July 2018

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Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

5 July 2018

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BRCA2 BRC motifs bind RAD51-DNA filaments

5 July 2018

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

5 July 2018

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RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair

5 July 2018

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Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis

5 July 2018

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DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

5 July 2018

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5 July 2018

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5 July 2018

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The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.

5 July 2018

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

5 July 2018

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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

5 July 2018

1 reference

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ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

BRCA2 is required for homology-directed repair of chromosomal breaks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations

5 July 2018

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Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240595

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002409

Proteasome Involvement in the Repair of DNA Double-Strand Breaks

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002409

Thymic lymphomas in mice with a truncating mutation in Brca2

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22194698

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12 December 2020

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Identifiers

DOI

10.1371/JOURNAL.PGEN.1002409

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22194698%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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19 January 2020

PubMed publication ID

22194698

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22194698%20AND%20SRC:MED&resulttype=core&format=json