Antibody regulation of B cell development (Q34076152)

7 January 2021

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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7 January 2021

Commitment to the B lymphoid lineage occurs before DH-JH recombination

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7 January 2021

The V(D)J recombination activating gene, RAG-1.

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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7 January 2021

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

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7 January 2021

Transcriptional regulation of early B-lymphocyte differentiation

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7 January 2021

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

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7 January 2021

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

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7 January 2021

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells

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7 January 2021

The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation

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7 January 2021

Antigen receptor tail clue.

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7 January 2021

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases

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7 January 2021

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

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7 January 2021

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

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7 January 2021

Analysis of the B-cell progenitor compartment at the level of single cells.

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7 January 2021

The status of Ig loci rearrangements in single cells from different stages of B cell development

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7 January 2021

Reading of D genes in variable frames as a source of antibody diversity

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7 January 2021

Analysis of junctional diversity during B lymphocyte development

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7 January 2021

Fit for life in the immune system? Surrogate L chain tests H chains that test L chains

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7 January 2021

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

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7 January 2021

Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells

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7 January 2021

B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames

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7 January 2021

Regulation of B lymphocyte development by the truncated immunoglobulin heavy chain protein Dmu.

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7 January 2021

Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

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7 January 2021

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

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7 January 2021

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

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7 January 2021

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

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7 January 2021

Development of the primary antibody repertoire

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7 January 2021

Extension of chromatin accessibility by nuclear matrix attachment regions.

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7 January 2021

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

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7 January 2021

Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines

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7 January 2021

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

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7 January 2021

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain

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7 January 2021

Antibody production by single cells

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7 January 2021

Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues

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7 January 2021

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

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7 January 2021

A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes.

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7 January 2021

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

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7 January 2021

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

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7 January 2021

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

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7 January 2021

Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice

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7 January 2021

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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7 January 2021

A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.

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7 January 2021

Mutations in the mu heavy-chain gene in patients with agammaglobulinemia

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7 January 2021

Autosomal primary immunodeficiencies affecting human bone marrow B-cell differentiation

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7 January 2021

Mutations in Igalpha (CD79a) result in a complete block in B-cell development

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7 January 2021

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

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7 January 2021

A critical role of λ5 protein in B cell development

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7 January 2021

B cell development in mice with a defective lambda 5 gene.

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7 January 2021

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

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7 January 2021

Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression

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7 January 2021

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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7 January 2021

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

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7 January 2021

Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci

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7 January 2021

Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice

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7 January 2021

Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition

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7 January 2021

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

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7 January 2021

Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein

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7 January 2021

The role of Ig beta in precursor B cell transition and allelic exclusion

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7 January 2021

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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7 January 2021

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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7 January 2021

Involvement of p59fynT in interleukin-5 receptor signaling

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7 January 2021

The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.

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7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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7 January 2021

Syk tyrosine kinase required for mouse viability and B-cell development

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7 January 2021

Requirement for B cell linker protein (BLNK) in B cell development

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7 January 2021

An essential role for BLNK in human B cell development

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7 January 2021

Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

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7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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7 January 2021

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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7 January 2021

Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

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7 January 2021

Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development

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7 January 2021

Developmentally controlled expression of immunoglobulin VH genes

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7 January 2021

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

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7 January 2021

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay

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7 January 2021

The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation

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7 January 2021

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

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7 January 2021

A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

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7 January 2021

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

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7 January 2021

Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements

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7 January 2021

Allelic exclusion in rat kappa immunoglobulin chains: extent of Jk rearrangement in normal B lymphocytes

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7 January 2021

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice

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7 January 2021

kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire

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7 January 2021

Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.

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7 January 2021

Two kappa immunoglobulin genes are expressed in the myeloma S107.

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7 January 2021

Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells

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7 January 2021

Activation of an excluded immunoglobulin allele in a human B lymphoma cell line

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7 January 2021

Kappa chain monoallelic demethylation and the establishment of allelic exclusion

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7 January 2021

Chromatin remodeling directly activates V(D)J recombination

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7 January 2021

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

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7 January 2021

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

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7 January 2021

Receptor editing in self-reactive bone marrow B cells

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7 January 2021

Four of five RAG-expressing JCkappa-/- small pre-BII cells have no L chain gene rearrangements: detection by high-efficiency single cell PCR

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7 January 2021

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

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7 January 2021

Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement

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7 January 2021

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

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7 January 2021

Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segment in a murine B cell line

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7 January 2021

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

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7 January 2021

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

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7 January 2021

Receptor editing: an approach by autoreactive B cells to escape tolerance

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7 January 2021

B lymphocytes may escape tolerance by revising their antigen receptors

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7 January 2021

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

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7 January 2021

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

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7 January 2021

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

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7 January 2021

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

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7 January 2021

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

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7 January 2021

The site and stage of anti-DNA B-cell deletion.

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7 January 2021

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

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7 January 2021

Receptor editing occurs frequently during normal B cell development.

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7 January 2021

The turnover of B-cell populations

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7 January 2021

Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter

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7 January 2021

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7 January 2021

Suppression of immunoglobulin class synthesis in mice. I. Effects of treatment with antibody to -chain

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7 January 2021

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

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7 January 2021

A transgenic model of autoimmune hemolytic anemia

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7 January 2021

Clonal anergy: the universally anergic B lymphocyte

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7 January 2021

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

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7 January 2021

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

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7 January 2021

B cells are anergic in transgenic mice that express IgM anti-DNA antibodies

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7 January 2021

Reduced life span of anergic self-reactive B cells in a double-transgenic model

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7 January 2021

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

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7 January 2021

A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

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7 January 2021

A critical role for complement in maintenance of self-tolerance

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7 January 2021

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

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7 January 2021

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

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7 January 2021

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

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7 January 2021

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

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7 January 2021

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

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7 January 2021

Inhibitory pathways triggered by ITIM-containing receptors.

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7 January 2021

Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence

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7 January 2021

Defective B cell development and function in Btk-deficient mice

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7 January 2021

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

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7 January 2021

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

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7 January 2021

CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

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7 January 2021

Hyperresponsive B cells in CD22-deficient mice

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7 January 2021

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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7 January 2021

Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.

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7 January 2021

Circulating human B cells that express surrogate light chains and edited receptors

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7 January 2021

Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs

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7 January 2021

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

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7 January 2021

Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population

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7 January 2021

Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production

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7 January 2021

Most peripheral B cells in mice are ligand selected

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7 January 2021

A B-cell receptor-specific selection step governs immature to mature B cell differentiation

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7 January 2021

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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7 January 2021

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

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7 January 2021

Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk

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7 January 2021

Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

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7 January 2021

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

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7 January 2021

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

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7 January 2021

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

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7 January 2021

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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7 January 2021

Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

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7 January 2021

Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells

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7 January 2021

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

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7 January 2021

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

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7 January 2021

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

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7 January 2021

Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells

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7 January 2021

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies

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7 January 2021

Rheumatoid factor secretion from human Leu-1+ B cells.

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7 January 2021

Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes

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7 January 2021

Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection.

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7 January 2021

Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression

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7 January 2021

Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment

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7 January 2021

Positive selection of natural autoreactive B cells

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7 January 2021

B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

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7 January 2021

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

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7 January 2021

Impaired expansion of mouse B cell progenitors lacking Btk.

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7 January 2021

Immunodeficiency in protein kinase cbeta-deficient mice

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7 January 2021

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

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7 January 2021

Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice

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7 January 2021

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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7 January 2021