Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland (Q34038494)

30 July 2017

title

Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland (English)

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30 July 2017

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Nadia Okolowsky

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30 July 2017

Priscilla A Furth

series ordinal

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30 July 2017

Paul A Hamel

series ordinal

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30 July 2017

language of work or name

English

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publication date

21 April 2014

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30 July 2017

published in

Developmental Biology

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30 July 2017

volume

391

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30 July 2017

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30 July 2017

page(s)

219-229

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Distinct effects of the mesenchymal dysplasia gene variant of murine Patched-1 protein on canonical and non-canonical Hedgehog signaling pathways

30 July 2017

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5 July 2018

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Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells

5 July 2018

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5 July 2018

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Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

5 July 2018

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Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.

5 July 2018

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ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression.

5 July 2018

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LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex

5 July 2018

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Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells

5 July 2018

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Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators

5 July 2018

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Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer.

5 July 2018

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Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

5 July 2018

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Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis

5 July 2018

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5 July 2018

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Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer

5 July 2018

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5 July 2018

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Development of mammary tumors by conditional expression of GLI1

5 July 2018

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Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation

5 July 2018

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Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse

5 July 2018

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Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

5 July 2018

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Novel link between estrogen receptor alpha and hedgehog pathway in breast cancer

5 July 2018

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Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide.

5 July 2018

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Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation

5 July 2018

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Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1

5 July 2018

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Estrogen receptors: how do they signal and what are their targets

5 July 2018

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Gli3-mediated repression of Hedgehog targets is required for normal mammary development

5 July 2018

1 reference

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Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

5 July 2018

1 reference

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c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling

5 July 2018

1 reference

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Introduction of estrogen receptor-alpha into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma

5 July 2018

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Estrogen receptor phosphorylation

5 July 2018

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Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

5 July 2018

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A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

5 July 2018

1 reference

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Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation

5 July 2018

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Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity

5 July 2018

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Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues.

5 July 2018

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Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation

5 July 2018

1 reference

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Estrogen receptor interaction with co-activators and co-repressors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

The nuclear receptor superfamily: the second decade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

HGF/SF: a potent cytokine for mammary growth, morphogenesis and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

A potent specific pure antiestrogen with clinical potential

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Interactions between MAP kinase and oestrogen receptor in human breast cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Conditional over-expression of estrogen receptor alpha in a transgenic mouse model

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131199

Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis

29 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2014.04.007

Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse

7 January 2021

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2014.04.007

10.1016/J.YDBIO.2014.04.007

7 January 2021

Identifiers

DOI

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30 July 2017

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30 July 2017

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