Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells (Q34026357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23852275%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells (English)

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

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5 March 2020

Wim Pierson

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5 March 2020

Bénédicte Cauwe

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5 March 2020

Antonia Policheni

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5 March 2020

Dean Franckaert

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5 March 2020

Julien Berges

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5 March 2020

Stephanie Humblet-Baron

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5 March 2020

Susann Schönefeldt

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5 March 2020

Antonio A Freitas

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5 March 2020

Rita J Luther

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5 March 2020

language of work or name

English

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publication date

14 July 2013

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5 March 2020

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volume

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issue

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5 March 2020

page(s)

959-965

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Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals

5 March 2020

cites work

1 reference

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5 July 2018

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The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

5 July 2018

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Homeostasis and function of regulatory T cells in aging

5 July 2018

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IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

5 July 2018

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Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis.

5 July 2018

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Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice

5 July 2018

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Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

5 July 2018

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Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

5 July 2018

1 reference

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Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

5 July 2018

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Human FoxP3+ regulatory T cells in systemic autoimmune diseases

5 July 2018

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Selective impairment of CD4+CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis

5 July 2018

1 reference

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A major role for Bim in regulatory T cell homeostasis.

5 July 2018

1 reference

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Mcl-1 is essential for germinal center formation and B cell memory

5 July 2018

1 reference

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FOXP3+ regulatory T cells in the human immune system

5 July 2018

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IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25

5 July 2018

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B cell receptor and BAFF receptor signaling regulation of B cell homeostasis

5 July 2018

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Intraclonal competition limits the fate determination of regulatory T cells in the thymus

5 July 2018

1 reference

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CTLA-4 control over Foxp3+ regulatory T cell function

5 July 2018

1 reference

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Dicer-dependent microRNA pathway safeguards regulatory T cell function

5 July 2018

1 reference

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Differentiation of regulatory Foxp3+ T cells in the thymic cortex

5 July 2018

1 reference

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Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

5 July 2018

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Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

5 July 2018

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The BCL-2 protein family: opposing activities that mediate cell death

5 July 2018

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Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

5 July 2018

1 reference

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A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

5 July 2018

1 reference

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Thymic development and peripheral homeostasis of regulatory T cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

A function for interleukin 2 in Foxp3-expressing regulatory T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

5 July 2018

1 reference

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

The role of BH3-only proteins in the immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

CD4+ CD25+ Treg: divide and rule?

5 July 2018

1 reference

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Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Rapid generation of inducible mouse mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

BH3-Only proteins-essential initiators of apoptotic cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Bclx regulates the survival of double-positive thymocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

RAG-1-deficient mice have no mature B and T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Dual Effects of TRAIL in Suppression of Autoimmunity: The Inhibition of Th1 Cells and the Promotion of Regulatory T Cells

5 July 2018

1 reference

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

21 January 2018

1 reference

Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61.

21 January 2018

1 reference

CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

21 January 2018

1 reference

The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Autologous regulation of naive T cell homeostasis within the T cell compartment.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128388

Foxp3-dependent programme of regulatory T-cell differentiation

29 October 2018

1 reference

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

21 January 2018

1 reference

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

21 January 2018

1 reference

12 December 2020

Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR mice

1 reference

12 December 2020

Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus

1 reference

12 December 2020

Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2649

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23852275%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23852275%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23852275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23852275%20AND%20SRC:MED&resulttype=core&format=json