The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain (Q34009371)

30 July 2017

title

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain (English)

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30 July 2017

main subject

transmembrane protein

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Konrad Beyreuther

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30 July 2017

Stefan F Lichtenthaler

object named as

Stefan F Lichtenthaler

1 reference

30 July 2017

Colin L Masters

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30 July 2017

Dirk Beher

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30 July 2017

Heike S Grimm

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30 July 2017

Rong Wang

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30 July 2017

Mark S Shearman

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30 July 2017

language of work or name

English

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publication date

22 January 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

1365-1370

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

30 July 2017

cites work

1 reference

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5 July 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

5 July 2018

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5 July 2018

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Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

5 July 2018

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

5 July 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

5 July 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

5 July 2018

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gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

5 July 2018

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

5 July 2018

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Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

5 July 2018

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Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

5 July 2018

1 reference

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

5 July 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

5 July 2018

1 reference

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

5 July 2018

1 reference

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Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

5 July 2018

1 reference

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

5 July 2018

1 reference

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Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

An investigation of the role of transmembrane domains in Golgi protein retention

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

A simple method for displaying the hydropathic character of a protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

5 July 2018

1 reference

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Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Amyloid beta-peptide is produced by cultured cells during normal metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122196

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11805291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11805291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11805291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.032395699

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference