Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors (Q34005966)

30 July 2017

title

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors (English)

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30 July 2017

Gitte Neubauer

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Toby Mathieson

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Yann Abraham

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Gerard Drewes

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Carsten Hopf

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Bernhard Kuster

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Marcus Bantscheff

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Dirk Eberhard

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Sonja Bastuck

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Markus Boesche

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Jessica Perrin

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Manfred Raida

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Valérie Reader

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Gavain Sweetman

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Tewis Bouwmeester

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Ulrich Kruse

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Nigel Ramsden

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Jens Rick

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Scott Hobson

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Christina Rau

series ordinal

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Andreas Bauer

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30 July 2017

publication date

26 August 2007

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30 July 2017

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page(s)

1035-1044

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Chemoproteomics-driven drug discovery: addressing high attrition rates

30 July 2017

cites work

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Large-scale proteomic analysis of the human spliceosome

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7 January 2021

Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors.

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7 January 2021

Discovery of novel targets of quinoline drugs in the human purine binding proteome

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

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7 January 2021

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

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7 January 2021

Large-scale analysis of the human and mouse transcriptomes

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7 January 2021

Functional analysis of discoidin domain receptor 1: effect of adhesion on DDR1 phosphorylation

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7 January 2021

NRH:quinone reductase 2: an enzyme of surprises and mysteries

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7 January 2021

Functional interrogation of the kinome using nucleotide acyl phosphates

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7 January 2021

Features of selective kinase inhibitors

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7 January 2021

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

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7 January 2021

Some parameters relevant to affinity chromatography on immobilized nucleotides

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7 January 2021

Sensing extracellular matrix: an update on discoidin domain receptor function

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7 January 2021

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop

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7 January 2021

Effect of STI-571 (imatinib mesylate) in combination with retinoic acid and gamma-irradiation on viability of neuroblastoma cells

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7 January 2021

Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis

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7 January 2021

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis

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7 January 2021

Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis

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7 January 2021

Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex

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7 January 2021

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases

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7 January 2021

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

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7 January 2021

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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7 January 2021

Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.

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7 January 2021

Identifiers

DOI

10.1038/NBT1328

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30 July 2017

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