Paired-like homeodomain transcription factor 2 (Q21989887)

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mammalian protein found in Mus musculus
  • BRX1 homeoprotein
  • ALL1-responsive protein ARP1
  • orthodenticle-like homeobox 2
  • pituitary homeobox 2
  • Homeobox protein PITX2
  • solurshin
  • Pitx2
  • paired-like homeodomain transcription factor Munc 30
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Language Label Description Also known as
English
Paired-like homeodomain transcription factor 2
mammalian protein found in Mus musculus
  • BRX1 homeoprotein
  • ALL1-responsive protein ARP1
  • orthodenticle-like homeobox 2
  • pituitary homeobox 2
  • Homeobox protein PITX2
  • solurshin
  • Pitx2
  • paired-like homeodomain transcription factor Munc 30

Statements

molecular function
DNA-binding transcription activator activity, RNA polymerase II-specific
determination method or standard
IBA
IEA
ISO
6 references
retrieved
11 October 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
ISO
retrieved
11 October 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IEA
retrieved
11 October 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IBA
retrieved
1 January 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
ISO
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IEA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IBA
cell component
nucleus
determination method or standard
IDA
IEA
ISO
6 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P97474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IEA
retrieved
16 July 2018
stated in
Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IDA
retrieved
16 July 2018
stated in
The Pitx2 protein in mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IDA
retrieved
16 July 2018
stated in
Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97474&geneProductId=UniProtKB:P97474
determination method or standard
IDA
biological process
heart development
determination method or standard
IGI
IMP
7 references
retrieved
14 February 2019
stated in
Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Regulation of left-right asymmetry by thresholds of Pitx2c activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Dosage requirement of Pitx2 for development of multiple organs
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IGI
determination of left/right symmetry
determination method or standard
IMP
7 references
retrieved
14 February 2019
stated in
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Regulation of left-right asymmetry by thresholds of Pitx2c activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Dosage requirement of Pitx2 for development of multiple organs
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP
retrieved
14 February 2019
stated in
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97474
determination method or standard
IMP

Identifiers

 
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