Insulin receptor substrate 2 (Q21986028)

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mammalian protein found in Mus musculus

• Irs2
• 4PS
• insulin receptor substrate 2

edit

Language	Label	Description	Also known as
English	Insulin receptor substrate 2	mammalian protein found in Mus musculus	Irs2 4PS insulin receptor substrate 2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P81122

subclass of

protein

1 reference

stated in

UniProt

retrieved

19 January 2017

UniProt protein ID

P81122

found in taxon

house mouse

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P81122

encoded by

Irs2

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P81122

molecular function

protein kinase binding

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

protein binding

determination method or standard

IPI

3 references

retrieved

9 May 2019

stated in

CDK4 is an essential insulin effector in adipocytes

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IPI

retrieved

9 May 2019

stated in

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IPI

retrieved

9 May 2019

stated in

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IPI

signal transducer activity

determination method or standard

IEA

IBA

2 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P81122

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IBA

insulin receptor binding

determination method or standard

IBA

IEA

ISO

4 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IBA

protein phosphatase binding

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

protein domain specific binding

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

phosphatidylinositol 3-kinase binding

determination method or standard

IDA

IEA

ISO

3 references

retrieved

21 June 2018

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

21 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

21 June 2018

stated in

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IDA

14-3-3 protein binding

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

phosphatidylinositol 3-kinase binding

determination method or standard

IBA

IDA

IEA

ISO

4 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IBA

cell component

cytosol

determination method or standard

IEA

IDA

TAS

3 references

retrieved

21 June 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

TAS

retrieved

21 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P81122

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

21 June 2018

stated in

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IDA

plasma membrane

determination method or standard

IDA

1 reference

retrieved

21 June 2018

stated in

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IDA

cytoplasm

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81122

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

protein-containing complex

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

CDK4 is an essential insulin effector in adipocytes

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

cytosol

determination method or standard

IBA

IDA

IEA

TAS

4 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81122

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IBA

plasma membrane

determination method or standard

IBA

IDA

2 references

retrieved

9 May 2019

stated in

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IBA

biological process

positive regulation of glucose metabolic process

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

regulation of lipid metabolic process

determination method or standard

IBA

1 reference

retrieved

21 June 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IBA

cellular response to insulin stimulus

determination method or standard

IEA

ISO

IDA

3 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

positive regulation of glycogen biosynthetic process

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

positive regulation of cell population proliferation

determination method or standard

IGI

1 reference

retrieved

14 February 2019

stated in

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IGI

positive regulation of fatty acid beta-oxidation

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

positive regulation of glucose import

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

cellular response to peptide

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

positive regulation of mesenchymal cell proliferation

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IGI

negative regulation of B cell apoptotic process

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

negative regulation of kinase activity

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

negative regulation of long-chain fatty acid import across plasma membrane

determination method or standard

IEA

ISO

2 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

response to glucose

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

cellular response to glucose stimulus

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

positive regulation of cell migration

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IGI

brain development

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

positive regulation of B cell proliferation

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IDA

cell population proliferation

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

signal transduction

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81122

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

positive regulation of insulin secretion

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

mammary gland development

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IGI

insulin receptor signaling pathway

determination method or standard

IEA

IMP

ISO

4 references

retrieved

21 June 2018

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

21 June 2018

stated in

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IMP

retrieved

21 June 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

21 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

determination method or standard

IEA

insulin receptor signaling pathway

determination method or standard

IBA

IEA

IMP

ISO

5 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

ISO

retrieved

9 May 2019

stated in

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IBA

positive regulation of cell population proliferation

determination method or standard

IGI

IMP

2 references

retrieved

9 May 2019

stated in

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IMP

retrieved

9 May 2019

stated in

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

determination method or standard

IGI

Identifiers

RefSeq protein ID

NP_001074681

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

384783

UniProt protein ID

P81122

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P81122

Ensembl protein ID

ENSMUSP00000038514

1 reference

stated in

ensembl Release 106

Ensembl protein ID

ENSMUSP00000038514

PDB structure ID

3BU3

1 reference

stated in

UniProt

UniProt protein ID

P81122

retrieved

10 August 2016

language of work or name

English

3BU5

1 reference

stated in

UniProt

UniProt protein ID

P81122

retrieved

10 August 2016

language of work or name

English

3BU6

1 reference

stated in

UniProt

UniProt protein ID

P81122

retrieved

10 August 2016

language of work or name

English

 

Sitelinks

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Wikibooks(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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