Abhydrolase domain containing 6 (Q21498774)

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mammalian protein found in Mus musculus

• monoacylglycerol lipase ABHD6
• 2-arachidonoylglycerol hydrolase
• Abhydrolase domain-containing protein 6
• Abhd6

edit

Language	Label	Description	Also known as
English	Abhydrolase domain containing 6	mammalian protein found in Mus musculus	monoacylglycerol lipase ABHD6 2-arachidonoylglycerol hydrolase Abhydrolase domain-containing protein 6 Abhd6

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q8R2Y0

part of

Alpha/Beta hydrolase fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8R2Y0

Epoxide hydrolase-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8R2Y0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Alpha/beta hydrolase fold-1, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

house mouse

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q8R2Y0

encoded by

Abhd6

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q8R2Y0

molecular function

catalytic activity

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

hydrolase activity

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

acylglycerol lipase activity

determination method or standard

IMP

IEA

ISO

IDA

6 references

retrieved

31 January 2018

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

ISO

retrieved

31 January 2018

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

retrieved

31 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

31 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

31 January 2018

stated in

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

31 January 2018

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

phospholipase activity

determination method or standard

IDA

1 reference

retrieved

31 January 2018

stated in

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

phospholipase activity

determination method or standard

IBA

IDA

2 references

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IBA

acylglycerol lipase activity

determination method or standard

IBA

IDA

IEA

IMP

ISO

8 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

ISO

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IBA

cell component

integral component of membrane

determination method or standard

IEA

IDA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

mitochondrion

determination method or standard

IEA

IDA

2 references

retrieved

31 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

31 January 2018

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

AMPA glutamate receptor complex

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

mitochondrion

determination method or standard

IBA

IDA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IBA

glutamatergic synapse

determination method or standard

EXP

IDA

2 references

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

SynGO

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

SynGO

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

EXP

GABA-ergic synapse

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

SynGO

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

integral component of postsynaptic membrane

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

SynGO

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

lysosomal membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

late endosome membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

lysosome

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

lysosomal membrane

determination method or standard

IDA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

endosome

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

late endosome membrane

determination method or standard

IDA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

mitochondrial membranes

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

biological process

long-term depression

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

regulation of endocannabinoid signaling pathway

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

positive regulation of lipid biosynthetic process

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

negative regulation of cell migration

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

acylglycerol catabolic process

determination method or standard

IEA

ISO

IDA

3 references

retrieved

31 January 2018

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

ISO

retrieved

31 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

31 January 2018

stated in

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R2Y0&geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

phospholipid catabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

acylglycerol catabolic process

determination method or standard

IBA

IDA

IEA

ISO

4 references

retrieved

9 May 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

ISO

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

retrieved

9 May 2019

stated in

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IBA

regulation of retrograde trans-synaptic signaling by endocanabinoid

determination method or standard

EXP

1 reference

retrieved

9 May 2019

stated in

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

GOA

curator

SynGO

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

EXP

negative regulation of cold-induced thermogenesis

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes.

GOA

curator

YuBioLab

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IMP

monoacylglycerol catabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

lysobisphosphatidic acid metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IDA

lipid metabolism

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8R2Y0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R2Y0

determination method or standard

IEA

has part(s)

Alpha/beta hydrolase fold-1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8R2Y0

Identifiers

RefSeq protein ID

NP_001317993

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

66082

NP_001317994

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

66082

NP_079617

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

66082

XP_006518136

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

66082

UniProt protein ID

Q8R2Y0

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q8R2Y0

Ensembl protein ID

ENSMUSP00000129169

1 reference

stated in

ensembl Release 106

Ensembl protein ID

ENSMUSP00000129169

ENSMUSP00000153068

1 reference

stated in

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153068

 

Sitelinks

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21498774&oldid=2023179366"