ER degradation enhancing alpha-mannosidase like protein 2 (Q21115848)

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mammalian protein found in Homo sapiens

• ER degradation-enhancing alpha-mannosidase-like 2
• EDEM2
• ER degradation enhancer, mannosidase alpha-like 2
• ER degradation-enhancing-mannosidase-like protein 2
• ER degradation-enhancing alpha-mannosidase-like protein 2

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Language	Label	Description	Also known as
English	ER degradation enhancing alpha-mannosidase like protein 2	mammalian protein found in Homo sapiens	ER degradation-enhancing alpha-mannosidase-like 2 EDEM2 ER degradation enhancer, mannosidase alpha-like 2 ER degradation-enhancing-mannosidase-like protein 2 ER degradation-enhancing alpha-mannosidase-like protein 2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9BV94

part of

Glycoside hydrolase family 47

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9BV94

Seven-hairpin glycosidases

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9BV94

Six-hairpin glycosidase-like superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9BV94

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9BV94

encoded by

EDEM2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9BV94

molecular function

calcium ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

determination method or standard

IDA

IMP

TAS

3 references

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BV94&geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

retrieved

10 September 2018

stated in

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BV94&geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

retrieved

10 September 2018

stated in

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

GOA

curator

UniProt

UniProt protein ID

Q9BV94

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BV94&geneProductId=UniProtKB:Q9BV94

determination method or standard

IDA

catalytic activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

determination method or standard

IDA

IMP

2 references

retrieved

8 April 2019

stated in

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

retrieved

8 April 2019

stated in

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

GOA

curator

UniProt

UniProt protein ID

Q9BV94

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IDA

cell component

endoplasmic reticulum lumen

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9BV94

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

endoplasmic reticulum

determination method or standard

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9BV94

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

retrieved

8 April 2019

stated in

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IDA

retrieved

8 April 2019

stated in

The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IDA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

endoplasmic reticulum quality control compartment

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

biological process

endoplasmic reticulum unfolded protein response

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BV94&geneProductId=UniProtKB:Q9BV94

determination method or standard

IBA

mannose trimming involved in glycoprotein ERAD pathway

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

N-glycan processing

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BV94&geneProductId=UniProtKB:Q9BV94

determination method or standard

IBA

positive regulation of retrograde protein transport, ER to cytosol

determination method or standard

IGI

IEA

IMP

3 references

retrieved

8 April 2019

stated in

The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

retrieved

8 April 2019

stated in

The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IGI

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

response to unfolded protein

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9BV94

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IEA

ubiquitin-dependent glycoprotein ERAD pathway

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

trimming of terminal mannose on B branch

determination method or standard

IMP

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

retrieved

8 April 2019

stated in

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

IMP

trimming of terminal mannose on C branch

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

trimming of first mannose on A branch

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

trimming of second mannose on A branch

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BV94

determination method or standard

TAS

Identifiers

RefSeq protein ID

NP_001138497

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

55741

NP_060687

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

55741

UniProt protein ID

Q9BV94

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9BV94

Ensembl protein ID

ENSP00000363615

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000363615

ENSP00000363616

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000363616

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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