3-phosphoinositide dependent protein kinase 1 (Q21114955)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

phospholipase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

insulin receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

21 June 2018

21 June 2018

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

21 June 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

phospholipase activator activity

EXP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

protein binding

7 references

8 April 2019

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Visualization of biochemical networks in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

10 September 2018

10 September 2018

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

10 September 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

protein serine/threonine kinase activity

EXP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

8 April 2019

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

cell projection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

focal adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

1 reference

10 September 2018

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

perikaryon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

postsynaptic density

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

cytoplasmic vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

intracellular signal transduction

biological process

1 reference

21 June 2018

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

1 reference

21 June 2018

extrinsic apoptotic signaling pathway

1 reference

8 April 2019

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of protein kinase activity

1 reference

8 April 2019

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

T cell costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

stimulatory C-type lectin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

positive regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

hyperosmotic response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15530&geneProductId=UniProtKB:O15530

1 reference

21 June 2018

platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

cellular response to epidermal growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

Fc-epsilon receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

positive regulation of phospholipase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of cardiac muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of toll-like receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

peptidyl-serine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

regulation of endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

cellular response to insulin stimulus

1 reference

8 April 2019

Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

protein autophosphorylation

1 reference

8 April 2019

PDK1, the master regulator of AGC kinase signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

regulation of mast cell degranulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

peptidyl-threonine phosphorylation

1 reference

8 April 2019

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

type B pancreatic cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

T cell receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

1 reference

8 April 2019

cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

actin cytoskeleton organization

1 reference

8 April 2019

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

cellular response to brain-derived neurotrophic factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

positive regulation of protein localization to plasma membrane

1 reference

8 April 2019

Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

MiR-492 impairs the angiogenic potential of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

positive regulation of angiogenesis

1 reference

8 April 2019

MiR-492 impairs the angiogenic potential of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

MiR-492 impairs the angiogenic potential of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

negative regulation of endothelial cell apoptotic process

1 reference

8 April 2019

Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15530

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8005

English

object of statement has role

17 August 2016

OSU-03012

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1650595

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

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1 reference

4 August 2016

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4 August 2016

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4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016