Itchy E3 ubiquitin protein ligase (Q21109507)

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mammalian protein found in Homo sapiens
  • atrophin-1 interacting protein 4
  • NFE2-associated polypeptide 1
  • NAPP1
  • AIP4
  • itchy E3 ubiquitin protein ligase homolog
  • E3 ubiquitin-protein ligase Itchy homolog
  • Atrophin-1-interacting protein 4
  • HECT-type E3 ubiquitin transferase Itchy homolog
  • ITCH
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Language Label Description Also known as
English
Itchy E3 ubiquitin protein ligase
mammalian protein found in Homo sapiens
  • atrophin-1 interacting protein 4
  • NFE2-associated polypeptide 1
  • NAPP1
  • AIP4
  • itchy E3 ubiquitin protein ligase homolog
  • E3 ubiquitin-protein ligase Itchy homolog
  • Atrophin-1-interacting protein 4
  • HECT-type E3 ubiquitin transferase Itchy homolog
  • ITCH

Statements

molecular function
protein binding
determination method or standard
IPI
22 references
retrieved
8 April 2019
stated in
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase Itch controls the protein stability of p63
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin-protein ligase Itch regulates p73 stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IPI
cell component
biological process
protein ubiquitination
determination method or standard
IBA
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IEA
retrieved
8 April 2019
stated in
Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IDA
retrieved
8 April 2019
stated in
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
GOA
curator
UniProt
UniProt protein ID
Q96J02
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02
determination method or standard
IBA

Identifiers

 
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