2'-5'-oligoadenylate synthetase 1 (Q21096374)

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mammalian protein found in Homo sapiens

p46/p42 OAS
E16 (2'-5') oligo A synthetase
2'-5'-oligoisoadenylate synthetase 1
OAS1
E18/E16
(2-5')oligo(A) synthase 1
2-5A synthase 1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
2',5'-oligo A synthetase 1
2'-5'-oligoadenylate synthase 1
2-5A synthetase 1

Language	Label	Description	Also known as
English	2'-5'-oligoadenylate synthetase 1	mammalian protein found in Homo sapiens	p46/p42 OAS E16 (2'-5') oligo A synthetase 2'-5'-oligoisoadenylate synthetase 1 OAS1 E18/E16 (2-5')oligo(A) synthase 1 2-5A synthase 1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2',5'-oligo A synthetase 1 2'-5'-oligoadenylate synthase 1 2-5A synthetase 1

Statements

1 reference

13 November 2019

UniProt protein ID

2'-5'-oligoadenylate synthase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00973

2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Polymerase, nucleotidyl transferase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, C-terminal conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

A Y2H-seq approach defines the human protein methyltransferase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

double-stranded RNA binding

determination method or standard

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

determination method or standard

3 references

8 April 2019

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

2'-5'-oligoadenylate synthetase activity

determination method or standard

5 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

2'-5'-oligoadenylate synthetase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

double-stranded RNA binding

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

2'-5'-oligoadenylate synthetase activity

determination method or standard

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

7 November 2018

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

determination method or standard

biological process

purine nucleotide biosynthetic process

determination method or standard

regulation of ribonuclease activity

determination method or standard

1 reference

27 February 2018

Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

glucose homeostasis

determination method or standard

1 reference

8 April 2019

New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

interferon-gamma-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

response to virus

determination method or standard

1 reference

8 April 2019

The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

negative regulation of viral genome replication

determination method or standard

2 references

27 February 2018

Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

defense response to virus

determination method or standard

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

27 February 2018

Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

type I interferon signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

protein complex oligomerization

determination method or standard

1 reference

27 February 2018

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

glucose metabolic process

determination method or standard

1 reference

8 April 2019

New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

cellular response to interferon-alpha

determination method or standard

1 reference

27 February 2018

Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

innate immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

negative regulation of viral genome replication

determination method or standard

defense response to virus

determination method or standard

3 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00973&geneProductId=UniProtKB:P00973

determination method or standard

regulation of ribonuclease activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

defense response to virus

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00973

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000202917

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000202917

ENSP00000388001

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388001

ENSP00000415721

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415721

ENSP00000448001

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448001

ENSP00000448348

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448348

ENSP00000448790

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448790

ENSP00000449053

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449053

ENSP00000450286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450286

ENSP00000474083

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000474083

ENSP00000475139

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475139

0 references

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(4 entries)

dewiki Oligoadenylatsynthetase 1
enwiki OAS1
ttwiki OAS1
ukwiki OAS1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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