Suppressor of variegation 205 Dmel_CG8409 (Q29809802)

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Protein found in Drosophila melanogaster

CG8409 gene product from transcript CG8409-RA
CG8409-PB
C1A9-nuclear-antigen
Su(var)205
CG8409-PA
Su(var)205-PB
heterochromatin protein-1
heterochromatin protein 1
heterochromatic protein 1
heterochromatin-binding protein
suppressor of variegated 205
heterochromatic protein 1a
heterochromatic protein
suppressor of variegation 205
heterochromatin factor 1
histone protein 1
Su(var)205-PA
heterochromatin protein 1A
Su(var)2-5
heterochromatin-protein-1

Language	Label	Description	Also known as
English	Suppressor of variegation 205 Dmel_CG8409	Protein found in Drosophila melanogaster	CG8409 gene product from transcript CG8409-RA CG8409-PB C1A9-nuclear-antigen Su(var)205 CG8409-PA Su(var)205-PB heterochromatin protein-1 heterochromatin protein 1 heterochromatic protein 1 heterochromatin-binding protein suppressor of variegated 205 heterochromatic protein 1a heterochromatic protein suppressor of variegation 205 heterochromatin factor 1 histone protein 1 Su(var)205-PA heterochromatin protein 1A Su(var)2-5 heterochromatin-protein-1

Statements

1 reference

25 May 2022

UniProt protein ID

Chromo-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

Chromo domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo shadow domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo/chromo shadow domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo domain subgroup, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method or standard

1 reference

1 January 2018

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

satellite DNA binding

determination method or standard

1 reference

1 January 2018

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

1 reference

1 January 2018

Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

1 reference

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

protein binding

determination method or standard

12 references

1 January 2018

Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Inheritance of stress-induced, ATF-2-dependent epigenetic change

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

A protein interaction map of Drosophila melanogaster

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

Hsp70 protein binding

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

protein-macromolecule adaptor activity

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

methylated histone binding

determination method or standard

1 reference

1 January 2018

Histone lysine methylation: a signature for chromatin function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

histone binding

determination method or standard

1 reference

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

RNA polymerase binding

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

RNA polymerase II C-terminal domain binding

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

1 reference

1 January 2018

Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

heterochromatin

determination method or standard

3 references

1 January 2018

Intercalary heterochromatin and genetic silencing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

condensed chromosome

determination method or standard

1 reference

1 January 2018

The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

5 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

determination method or standard

1 reference

1 January 2018

Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

polytene chromosome

determination method or standard

3 references

1 January 2018

Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

polytene chromosome chromocenter

determination method or standard

6 references

1 January 2018

Intercalary heterochromatin and genetic silencing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Inheritance of stress-induced, ATF-2-dependent epigenetic change

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

polytene chromosome puff

determination method or standard

4 references

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

polytene chromosome band

determination method or standard

1 reference

1 January 2018

Inheritance of stress-induced, ATF-2-dependent epigenetic change

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

polytene chromosome interband

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

pericentric heterochromatin

determination method or standard

1 reference

1 January 2018

Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

biological process

mitotic cell cycle

determination method or standard

1 reference

1 January 2018

MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

telomere maintenance

determination method or standard

1 reference

1 January 2018

HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

regulation of histone methylation

determination method or standard

1 reference

1 January 2018

Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

heterochromatin assembly

determination method or standard

1 reference

1 January 2018

Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

histone H4-K20 trimethylation

determination method or standard

1 reference

1 January 2018

Preferential dimethylation of histone H4 lysine 20 by Suv4-20

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

DNA hypermethylation

determination method or standard

1 reference

1 January 2018

Retracted: SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

1 January 2018

Is HP1 an RNA detector that functions both in repression and activation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

chromosome organization

determination method or standard

1 reference

1 January 2018

The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

positive regulation of DNA methylation-dependent heterochromatin assembly

determination method or standard

1 reference

1 January 2018

Panoramix enforces piRNA-dependent cotranscriptional silencing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

positive regulation of histone H3-K9 dimethylation

determination method or standard

protein localization to euchromatin

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

regulation of protein localization to chromatin

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

positive regulation of FACT complex assembly

determination method or standard

1 reference

1 January 2018

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05205&geneProductId=UniProtKB:P05205

determination method or standard

Chromo shadow domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

Chromo domain subgroup

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

Chromo domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

Chromo/chromo shadow domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05205

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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