Pregnane X receptor and natural products: beyond drug-drug interactions (Q28748504)

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scientific article (publication date: December 2006)

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English	Pregnane X receptor and natural products: beyond drug-drug interactions	scientific article (publication date: December 2006)

Statements

instance of

scholarly article

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review article

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stated in

Europe PubMed Central

title

Pregnane X receptor and natural products: beyond drug-drug interactions (English)

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main subject

natural product

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based on heuristic

inferred from title

drug interaction

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drug metabolism

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based on heuristic

inferred from title

author name string

Jeff L Staudinger

series ordinal

1

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Xunshan Ding

series ordinal

2

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Kristin Lichti

series ordinal

3

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language of work or name

English

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publication date

December 2006

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published in

Expert Opinion on Drug Metabolism & Toxicology

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volume

2

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issue

6

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page(s)

847-57

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cites work

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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16 March 2017

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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16 March 2017

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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16 March 2017

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

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16 March 2017

Steroid receptor coactivator-1 is a histone acetyltransferase

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16 March 2017

The nuclear receptor superfamily: the second decade

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16 March 2017

ET-743: a novel agent with activity in soft-tissue sarcomas

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3 June 2018

Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.

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PubMed Central

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3 June 2018

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor

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PubMed Central

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3 June 2018

St John's wort-associated drug interactions: short-term inhibition and long-term induction?

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3 June 2018

Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

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PubMed Central

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3 June 2018

Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin

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PubMed Central

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3 June 2018

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

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PubMed Central

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3 June 2018

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites

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3 June 2018

The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand

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3 June 2018

Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.

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3 June 2018

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

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PubMed Central

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3 June 2018

Regulation of Drug Transporter Gene Expression by Nuclear Receptors

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3 June 2018

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

1 reference

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PubMed Central

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3 June 2018

Kava-kava and anxiety: growing knowledge about the efficacy and safety

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3 June 2018

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

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PubMed Central

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3 June 2018

Regulation of cyp3a gene transcription by the pregnane x receptor

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3 June 2018

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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PubMed Central

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3 June 2018

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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3 June 2018

St John's wort, a herbal antidepressant, activates the steroid X receptor.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978027

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3 June 2018

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

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PubMed Central

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3 June 2018

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

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3 June 2018

The taxanes: an update

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3 June 2018

Ancient-modern concordance in Ayurvedic plants: some examples

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3 June 2018

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

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3 June 2018

Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of gamma-glutamyl transpeptidase

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3 June 2018

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3 June 2018

Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients

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3 June 2018

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells

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3 June 2018

Forskolin: from an ayurvedic remedy to a modern agent

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3 June 2018

Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.

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3 June 2018

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

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21 January 2018

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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21 January 2018

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

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21 January 2018

Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile

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Crossref

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21 January 2018

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

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Crossref

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21 January 2018

Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics

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Crossref

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21 January 2018

A natural product that lowers cholesterol as an antagonist ligand for FXR.

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Crossref

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21 January 2018

The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter

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Crossref

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21 January 2018

Inhibition of human cytochrome P450 activities by kava extract and kavalactones

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21 January 2018

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

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21 January 2018

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

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21 January 2018

Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats

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21 January 2018

Vitamin E activates gene expression via the pregnane X receptor

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21 January 2018

Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity

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21 January 2018

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

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27 November 2018

Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats

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12 December 2020

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Effect of gugulipid on bioavailability of diltiazem and propranolol

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PubMed

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12 December 2020

based on heuristic

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Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP

1 reference

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17125405

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12 December 2020

based on heuristic

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Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17125405

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1517/17425255.2.6.847

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4033799

OpenCitations bibliographic resource ID

4033799

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4033799

PMC publication ID

2978027

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4033799

PubMed publication ID

17125405

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4033799

ResearchGate publication ID

6673611

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