Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease (Q28731520)

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English	Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease	scientific article (publication date: 2012)

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instance of

scholarly article

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title

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease (English)

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main subject

Alzheimer's disease

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based on heuristic

inferred from title

preproinsulin

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based on heuristic

inferred from title

acceleration

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author

Stephen D Ginsberg

object named as

Stephen D Ginsberg

series ordinal

3

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Melissa J. Alldred

series ordinal

2

object named as

Melissa J Alldred

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author name string

Latha Devi

series ordinal

1

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Masuo Ohno

series ordinal

4

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

3

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page(s)

e32792

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copyright license

Creative Commons Attribution 4.0 International

start time

5 March 2012

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stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

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A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models

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Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

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Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.

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Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

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Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

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Ubiquitin regulates GGA3-mediated degradation of BACE1

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3 June 2018

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

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3 June 2018

Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice

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Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice

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Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice

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3 June 2018

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease

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3 June 2018

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

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3 June 2018

Alzheimer's disease is type 3 diabetes-evidence reviewed

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3 June 2018

Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and diabetes mellitus type-2.

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3 June 2018

Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis

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PubMed Central

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3 June 2018

Failures to reconsolidate memory in a mouse model of Alzheimer's disease

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3 June 2018

Terminal Continuation (TC) RNA amplification enables expression profiling using minute RNA input obtained from mouse brain

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3 June 2018

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

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3 June 2018

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

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3 June 2018

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

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3 June 2018

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

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3 June 2018

Transcriptional profiling of small samples in the central nervous system

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3 June 2018

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

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3 June 2018

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

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PubMed Central

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3 June 2018

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

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3 June 2018

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

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3 June 2018

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

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21 January 2018

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

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21 January 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

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Crossref

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032792

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21 January 2018

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

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21 January 2018

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

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21 January 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

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21 January 2018

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

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21 January 2018

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

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21 January 2018

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

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21 January 2018

Metabolic regulation of brain Abeta by neprilysin

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21 January 2018

Insulin induces dephosphorylation of eukaryotic initiation factor 2alpha and restores protein synthesis in vulnerable hippocampal neurons after transient brain ischemia

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21 January 2018

Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue

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21 January 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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21 January 2018

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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Crossref

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21 January 2018

BACE1 mRNA Expression in Alzheimer's Disease Postmortem Brain Tissue

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Crossref

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21 January 2018

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

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Crossref

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21 January 2018

The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease

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Crossref

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21 January 2018

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

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Crossref

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21 January 2018

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

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PubMed

reference URL

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retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1371/JOURNAL.PONE.0032792

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2475065

ADS bibcode

2012PLoSO...732792D

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Fatcat ID

release_azduwvhju5geterz4vxklxiidy

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Fatcat

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https://api.fatcat.wiki/v0/release/azduwvhju5geterz4vxklxiidy

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24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

2475065

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2475065

PMC publication ID

3293895

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2475065

PubMed publication ID

22403710

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2475065

ResearchGate publication ID

221689589

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