Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity (Q28540626)

30 October 2023

Veronica T Campbell

Veronica T

Campbell

1 reference

30 October 2023

Joseph A Harari

Joseph A

Harari

1 reference

30 October 2023

Thomas T Tibbitts

Thomas T

Tibbitts

1 reference

30 October 2023

Jennifer L Proctor

Jennifer L

Proctor

1 reference

30 October 2023

Nigel Whitebread

Nigel

Whitebread

1 reference

30 October 2023

James M Conley

James M

Conley

1 reference

30 October 2023

Kerry F White

Kerry F

White

1 reference

30 October 2023

Jeffery L Kutok

Jeffery L

Kutok

1 reference

30 October 2023

Margaret A Read

Margaret A

Read

1 reference

30 October 2023

Karen McGovern

Karen

McGovern

1 reference

30 October 2023

Kerrie L Faia

Kerrie L

Faia

1 reference

Creative Commons Attribution 4.0 International

30 October 2023

language of work or name

English

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publication date

2014

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e90534

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start time

7 March 2014

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Structure of the human smoothened receptor bound to an antitumour agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Patched1 regulates hedgehog signaling at the primary cilium

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Hedgehog signaling in development and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

A paracrine requirement for hedgehog signalling in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

Induction of osteogenic differentiation by hedgehog proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946503

10.1371/JOURNAL.PONE.0090534

29 September 2017

Identifiers

DOI

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